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Analysis of institutional authors

Mari Ayala, MartaAuthorTutusaus ACorresponding AuthorMorales AAuthorGarcia De Frutos PAuthorMari MAuthor
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Review

GAS6/TAM Axis as Therapeutic Target in Liver Diseases

Publicated to:Seminars In Liver Disease. 44 (1): 99-114 - 2024-03-21 44(1), DOI: 10.1055/a-2275-0408

Authors: Tutusaus, Anna; Morales, Albert; de Frutos, Pablo Garcia; Mari, Montserrat

Affiliations

Barcelona Clin Liver Canc BCLC Grp, Barcelona, Spain - Author
Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Barcelona, Comunidad De Ma, Spain - Author
IIBB CSIC, IDIBAPS, Dept Cell Death & Proliferat, Barcelona, Catalunya, Spain - Author
IIBB-CSIC, IDIBAPS, Barcelona, Spain. - Author
Inst Invest Biomed Barcelona IIBB CSIC, C Rossello 161,6th Floor, Barcelona 08036, Catalunya, Spain - Author
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Abstract

TAM (TYRO3, AXL and MERTK) protein tyrosine kinase membrane receptors and their vitamin K-dependent ligands GAS6 and Protein S (PROS) are well-known players in tumor biology and autoimmune diseases. In contrast, TAM regulation of fibrogenesis and the inflammation mechanisms underlying metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis and, ultimately, liver cancer has recently been revealed. GAS6 and PROS binding to phosphatidylserine exposed in outer membranes of apoptotic cells links TAMs, particularly MERTK, with hepatocellular damage. In addition, AXL and MERTK regulate the development of liver fibrosis and inflammation in chronic liver diseases. Acute hepatic injury is also mediated by the TAM system, as recent data regarding acetaminophen toxicity and acute-on-chronic liver failure have uncovered. Soluble TAM-related proteins, mainly released from activated macrophages and hepatic stellate cells after hepatic deterioration, are proposed as early serum markers for disease progression. In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field.

Keywords
Axl receptor tyrosine kinaseC-mer tyrosine kinaseHumansInflammationLiver cirrhosisReceptor protein-tyrosine kinases

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Seminars In Liver Disease due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 30/143, thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology & Hepatology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-16:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 2
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Tutusaus López, Anna) and Last Author (Marí García, Montserrat).

the author responsible for correspondence tasks has been Tutusaus López, Anna.