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Otorhinolaryngological manifestations in monkeypox.

Publicated to:Acta Otorrinolaringologica Espanola. 74 (4): 263-267 - 2023-01-01 74(4), DOI: 10.1016/j.otoeng.2023.05.005

Authors: Alegre B; Jubés S; Arango N; Pastene D; Lehrer E; Vilaseca I

Affiliations

2.08.01 - Immunoal·lèrgia respiratòria clínica i experimental (IRCE). Institut d'Investigacions Biomèdiques August Pi i Sunyer - Author
Servicio de Otorrinolaringología, Hospital Clínic, Barcelona, Spain. - Author
Servicio de Otorrinolaringología, Hospital Clínic, Barcelona, Spain. Electronic address: balegre@clinic.cat. - Author
Servicio de Otorrinolaringología, Hospital Clínic, Barcelona, Spain; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain. - Author

Abstract

In the current health emergency declared by the World Health Organization (WHO) for monkeypox, few data on the otorhinolaryngological (ENT) manifestations of the disease have been detailed. The purpose of this study is to describe the clinical features of the ENT manifestations in monkeypox. Descriptive analysis of 11 consecutive patients with odynodysphagia or oral cavity lesions referred to the ENT emergency department of a tertiary hospital with epidemiological risk factors suggestive of monkeypox infection. Clinical, diagnostic and treatment findings are described. 90.9% of the patients had previous unsafe sexual contact. The predominant presenting features included fever over 38 °C with severe odynodysphagia. Physical examination showed ulcers and exudative lesions of variable presentation in the upper respiratory tract. Smear of the lesions confirmed polymerase chain reaction (PCR) positivity for monkeypox in all patients. Monkeypox virus infection can occur in the ENT area with multiple manifestations that require a high degree of epidemiological suspicion and confirmation with PCR to reach a diagnosis of certainty. En la actual emergencia sanitaria declarada por la Organización Mundial de la Salud (OMS) por viruela del mono se han detallado pocos datos sobre las manifestaciones otorrinolaringológicas (ORL) de dicha enfermedad. El propósito del estudio pretende describir las características clínicas de las manifestaciones ORL de la viruela del mono. Análisis descriptivo de 11 pacientes consecutivos con odinodisfagia o lesiones de cavidad oral derivados al área de urgencias de ORL de un hospital terciario con factores de riesgo epidemiológicos que pudieran sugerir infección por viruela del mono. Se describen los hallazgos clínicos, diagnósticos y de tratamiento. El 90,9% de los pacientes habían tenido contacto sexual de riesgo previo. El cuadro de presentación predominante incluía fiebre de más de 38 °C con odinodisfagia intensa. El examen físico mostraba úlceras y lesiones exudativas de presentación variable en la vía aerodigestiva superior. El frotis de las lesiones confirmó positividad en la reacción en cadena de la polimerasa (PCR) para viruela del mono en todos los pacientes. La infección por virus de viruela del mono puede presentarse en el área ORL con múltiples manifestaciones que precisan de un grado de sospecha epidemiológico alto y la confirmación con PCR para llegar a un diagnóstico de certeza.

Keywords

AdenopathyAdenopatíaAmigdalitisConducta sexual de riesgoEmergency service, hospitalFeverHumansLarynxMonkeypoxMpox (monkeypox)NoseOdinofagiaOdynophagiaPrepTonsillitisUlcerÚlceraUnsafe sexual contactViruela del mono

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acta Otorrinolaringologica Espanola, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Otorhinolaryngology, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 8.35, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-15, the following number of citations:

  • OpenCitations: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).