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Grant support

This study was partially supported by Fujimori Kogyo Co., Instituto de Salud Carlos III (FIS PI19/00888) , Fundacio Marato de TV3 (202026-10) , and Generalitat de Catalunya (2017-SGR675, CERCA) .

Analysis of institutional authors

Moreno-Castano, Ana BAuthorPino, MarcAuthorTorramade-Moix, SergiAuthorMartinez-Sanchez, JuliaAuthorLozano Molero, MiguelAuthorSanz, CristinaAuthorEscolar, GinesAuthorDiaz-Ricart, MaribelCorresponding Author

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June 2, 2024
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T-TAS® 01 as a new tool for the evaluation of hemostasis in thrombocytopenic patients after platelet transfusion

Publicated to:Blood Transfusion. 22 (2): 166-175 - 2024-04-01 22(2), DOI: 10.2450/bloodtransfus.550

Authors: Samanbar, Sahar; Pineyroa, Juan A; Moreno-Castano, Ana B; Pino, Marc; Torramade-Moix, Sergi; Martinez-Sanchez, Julia; Sanz, Cristina; Escolar, Gines; Diaz-Ricart, Maribel

Affiliations

Banc Sang Teixits BST 1, Transfus Dept, Barcelona, Spain - Author
Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain - Author
Univ Barcelona, Hosp Clin, Hematopathol Pathol Dept, CDB,IDIBAPS, Barcelona, Spain - Author
Univ Barcelona, Hosp Clin, Josep Carreras Leukemia Res Inst, Barcelona, Spain - Author

Abstract

Background - Current laboratory tests fail to evaluate the hemostatic function of platelets in patients with thrombocytopenia. We investigated the use of the Total Thrombus -Formation Analysis System (T-TAS (R) 01 [Fujimori Kogyo Co, Tokyo, Japan]) to evaluate hemostasis under conditions of experimental thrombocytopenia, and in patients before and after platelet transfusion. Materials and methods - Specific T-TAS 01 chips, for thrombocytopenic conditions, were used. The area under the curve (AUC) and occlusion time (OT, min) were measured in: (i) experimentally induced thrombocytopenia (183 +/- 15 to 6.3 +/- 1.2x10 3 platelets/mu L) in blood samples from healthy donors (No.=13), and (ii) blood from oncohematological thrombocytopenic patients (No.=48), before and after platelet transfusion. The influences of hematocrit and number of transfusions were analyzed in these patients. Results - Progressive reductions of AUC and prolongations of OT related significantly to decreasing platelet counts (p

Keywords

Acute leukemiaAcute lymphoblastic leukemiaAcute myeloid leukemiaAdultAntineoplastic agentArea under the curveArticleBleedingBleeding-timeBloodBlood clottingBlood plateletsBlood samplingBone marrow depressionChronic myeloid leukemiaClinical articleClinical-practice guidelineControlled studyErythrocyte transfusionFemaleHematocritHematopoietic stem cellHemostasisHemostatic agentHemostaticsHumanHumansImmunological antineoplastic agentImmunopathologyInfectionLaboratory testLymphomaMaleMalignanciesMedicinOcclusionPlatelet countPlatelet transfusionPortal hypertensionSepsisSplenomegalyThrombocyteThrombocyte concentrateThrombocyte functionThrombocyte transfusionThrombocytopeniaTotal thrombus-formation analysis system (t-tas)

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Blood Transfusion due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 46/97, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Hematology. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.16, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-17, the following number of citations:

  • WoS: 3
  • Scopus: 3
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Samanbar, Sahar) and Last Author (Díaz Ricart, Maribel).

the author responsible for correspondence tasks has been Díaz Ricart, Maribel.