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Analysis of institutional authors

Marco, DnAuthorMolina, MAuthorGuio, AmAuthorFortuna, VAuthorSalas, MqAuthorSuarez-Lledo, MAuthorRosinol, LAuthorFernandez-Aviles, FAuthorRovira MAuthorRovira, MAuthorBrunet, MAuthorMartinez CAuthor

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July 3, 2024
Publications
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Article

Effects of CYP3A5 Genotype on Tacrolimus Pharmacokinetics and Graft-versus-Host Disease Incidence in Allogeneic Hematopoietic Stem Cell Transplantation

Publicated to: Pharmaceuticals. 17 (5): 553- - 2024-05-01 17(5), DOI: 10.3390/ph17050553

Authors: Marco, DN; Molina, M; Guio, AM; Julian, J; Fortuna, V; Fabregat-Zaragoza, VL; Salas, MQ; Monge-Escartín, I; Riu-Viladoms, G; Carcelero, E; Roma, JR; Llobet, N; Arcarons, J; Suárez-Lledó, M; Rosiñol, L; Fernández-Avilés, F; Rovira, M; Brunet, M; Martínez, C

Affiliations

Hosp Clin Barcelona, Biomed Diagnost Ctr, Biochem & Mol Genet Dept, Pharmacol & Toxicol Lab,IDIBAPS,CIBERehd - Author
Hosp Clin Barcelona, Dept Immunol - Author
Hosp Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Inst Canc & Hematol Dis, Hematol Dept,Hematopoiet Stem Cell Transplantat Un - Author
Hosp Clin Barcelona, Pharm Serv, Dept Pharm - Author
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Abstract

Tacrolimus (Tac) is pivotal in preventing acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT). It has been reported that genetic factors, including CYP3A5*3 and CYP3A4*22 polymorphisms, have an impact on Tac metabolism, dose requirement, and response to Tac. There is limited information regarding this topic in alloHSCT. The CYP3A5 genotype and a low Tac trough concentration/dose ratio (Tac C-0/D ratio) can be used to identify fast metabolizers and predict the required Tac dose to achieve target concentrations earlier. We examined 62 Caucasian alloHSCT recipients with a fast metabolizer phenotype (C-0/dose ratio

Keywords

Acute leukemiaAdultAgedAlleleAllogeneic hematopoietic stem cell transplantationArticleBloodCreatinine blood levelCreatinine clearanceCyp3a5 genotypeCytochrome p450 3a5FemaleGene mutationGenotypeGraft versus host reactionGraft-versus-host diseaseHematocritHematopoietic stem cell transplantationHumanIncidenceMajor clinical studyMaleManagementMetabolismMiddle agedMyelodysplastic syndromeMyeloproliferative disorderPharmacodynamicsPharmacogeneticsPhenotypePolymerase chain reactionPreemptive pharmacogeneticsSingle nucleotide polymorphismSingle nucleotide polymorphismsTacrolimusTherapeutic drug monitoringThrombotic microangiopathyYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Pharmaceuticals due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 51/352, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-15:

  • WoS: 5
  • Scopus: 4
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-15:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Marco Prats, Daniel Nicolás) and Last Author (Martínez Muñoz, Carmen).