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Analysis of institutional authors

Sanfeliu-Redondo, DAuthorGibert-Ramos, AAuthorGracia-Sancho, JCorresponding Author

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Review

Cell senescence in liver diseases: pathological mechanism and theranostic opportunity

Publicated to:Nature Reviews Gastroenterology & Hepatology. 21 (7): 477-492 - 2024-06-01 21(7), DOI: 10.1038/s41575-024-00913-4

Authors: Sanfeliu-Redondo, D; Gibert-Ramos, A; Gracia-Sancho, J

Affiliations

CIBEReHD - Author
Univ Bern, Dept Visceral Surg & Med, Inselspital - Author

Abstract

The liver is not oblivious to the passage of time, as ageing is a major risk factor for the development of acute and chronic liver diseases. Ageing produces alterations in all hepatic cells, affecting their phenotype and function and worsening the prognosis of liver disease. The ageing process also implies the accumulation of a cellular state characterized by a persistent proliferation arrest and a specific secretory phenotype named cellular senescence. Indeed, senescent cells have key roles in many physiological processes; however, their accumulation owing to ageing or pathological conditions contributes to the damage occurring in chronic diseases. The aim of this Review is to provide an updated description of the pathophysiological events in which hepatic senescent cells are involved and their role in liver disease progression. Finally, we discuss novel geroscience therapies that could be applied to prevent or improve liver diseases and age-mediated hepatic deregulations. Ageing and senescence are major risk factors for liver disease development. This Review provides a comprehensive overview of hepatic senescence, its role in liver disease progression and hepatocellular carcinoma, and discusses potential therapeutic strategies. Senescent hepatocytes undergo morphological changes and metabolic alterations, negatively affecting liver function and promoting disease progression.Structural and functional changes in senescent liver sinusoidal endothelial cells contribute to liver disease.In the initial stages of liver disease, hepatic stellate cells undergo senescence, facilitating liver regeneration and fibrosis regression. Conversely, during cirrhosis, the increase in their number induces inflammation, promoting hepatocellular carcinoma (HCC).Senescence has a role in the development and progression of metabolic dysfunction-associated steatotic liver disease and viral hepatitis, contributing to liver injury, inflammation, fibrosis and HCC.Senescence can protect against HCC, inhibiting the growth of damaged cells; it can also lead to HCC progression by promoting inflammation and creating a pro-tumoural microenvironment within the liver.Senotherapeutic strategies, drug repurposing, and lifestyle interventions hold potential as therapies for liver disease by targeting and eliminating senescent cells and counteracting the harmful effects of senescence and ageing.

Keywords

Age-related-changesAgingCell agingCellular senescenceChimeric antigen receptorChronic liver diseaseDasatinibDisease exacerbationDisease progressionDna damageFibrosis progressionForkhead transcription factorHeat shock protein 90 inhibitorHepatic stellate cellsHepatocyte senescenceHumanHumansImmune-responsesKupffer cellsLiverLiver cellLiver cell carcinomaLiver diseaseLiver diseasesLiver sinusoidal endothelial cellMetforminNk cellPathologyPathophysiologyPhenotypePhysiologyReactive oxygen metaboliteReplicative senescenceResveratrolReviewRisk-factorsSecretory phenotypeTheranostic nanomedicineTherapy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nature Reviews Gastroenterology & Hepatology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 1/143, thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology & Hepatology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-22:

  • WoS: 6
  • Scopus: 23

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 42.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 42 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 15.35.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 24 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Switzerland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Sanfeliu Redondo, David) and Last Author (Gracia Sancho, Jordi).

the author responsible for correspondence tasks has been Gracia Sancho, Jordi.