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Grant support

This study was supported by grants from the Spanish MICINN (SAF2009-13093-C02-02; CSD2010-00045), FISS-06-RD06/0013/0011, and CIBERNED from the "Instituto de Salud Carlos III, 610RT0405 from Programa Iberoamericano de Ciencia y Tecno para el Desarrollo (CYTED); and the Catalan Generalitat (DURSI 2009/SGR/214; 2009/SGR00893). We gratefully acknowledge the contribution of Dr S Garcia-Matas and Dr J Gutierrez-Cuesta to the preliminary studies. We thank A. Parull for his skillful technical assistance.

Analysis of institutional authors

Cristofol, RosaAuthorCorpas, RubenAuthorCoto-Montes, AnaAuthorSanfeliu, CoralCorresponding Author

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Article

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

Publicated to:Journal Of Pineal Research. 52 (3): 271-281 - 2012-04-01 52(3), DOI: 10.1111/j.1600-079X.2011.00939.x

Authors: Cristofol, Rosa; Porquet, David; Corpas, Ruben; Coto-Montes, Ana; Serret, Jofre; Camins, Antoni; Pallas, Merce; Sanfeliu, Coral

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Abstract

The senescence-accelerated prone 8 (SAMP8) mouse strain shows early cognitive loss that mimics the deterioration of learning and memory in the elderly and is widely used as an animal model of aging. SAMP8 mouse brain suffers oxidative stress, as well as tau- and amyloid-related pathology. Mitochondrial dysfunction and the subsequent increase in cellular oxidative stress are central to the aging processes of the organism. Here, we examined the mitochondrial status of neocortical neurons cultured from SAMP8 and senescence-accelerated-resistant (SAMR1) mice. SAMP8 mouse mitochondria showed a reduced membrane potential and higher vulnerability to inhibitors and uncouplers than SAMR1 mitochondria. dl-buthionine-[S,R]-sulfoximine (BSO) caused greater oxidative damage in neurons from SAMP8 mice than in those from SAMR1 mice. This increased vulnerability, indicative of frailty-associated senescence, was protected by the anti-aging agents melatonin and resveratrol. The sirtuin 1 inhibitor, sirtinol, demonstrated that the neuroprotection against BSO was partially mediated by increased sirtuin 1 expression. Melatonin, like resveratrol, enhanced sirtuin 1 expression in neuron cultures of SAMR1 and SAMP8 mice. Therefore, a deficiency in the neuroprotection and longevity of the sirtuin 1 pathway in SAMP8 neurons may contribute to the early age-related brain damage in these mice. This supports the therapeutic use of sirtuin 1-enhancing agents against age-related nerve cell dysfunction and brain frailty.

Keywords

Activated protein-kinaseAging brainAging researcAlzheimers-diseaseAnimalsCells, culturedCerebral-cortexCognitive declineIn-vitroLong-termMelatoninMembrane potentialsMetabolismMiceMitochondriaMitochondrial dysfunctionMouse samNeuronsNeuroprotective capacityNf-kappa-bNitric-oxide synthaseOxidative stressReactive oxygen speciesResveratrolSamp8 mouse neuron culturesSirtuinSirtuin 1StilbenesTime factors

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Pineal Research due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 4/80, thus managing to position itself as a Q1 (Primer Cuartil), in the category Physiology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.76. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.27 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 13.53 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-02, the following number of citations:

  • WoS: 80
  • Scopus: 94
  • Europe PMC: 50
  • OpenCitations: 89

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 76.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 76 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.5.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Cristofol Martinez, Rosa) and Last Author (Sanfeliu Pujol, Coral).

the author responsible for correspondence tasks has been Sanfeliu Pujol, Coral.