{rfName}
MY

Indexed in

License and use

Citations

3

Altmetrics

Grant support

This work was supported by Asociacion Espanola Contra el Cancer (PRYGN21911-SALA), Fondo de Investigaciones Sanitarias Instituto de Salud Carlos III (PI18/00471, PI21/00479) to IS, and PID2021-123054OB-I00 funded by MCIN/AEI/10.13039/501100011033 to EC and, as appropriate, by "ERDF A way of making Europe". Furthermore, the authors would like to thank the support of the Generalitat de Catalunya Support Grups de Recerca (2017-SGR-1107 and 2021-SGR-01293 to IS and 2021-SGR-01172 to EC). IS was supported by Miguel Servet II ISCIII (MS18/00015). SM holds a PFIS ISCIII fellowship (FI22/00063), AC holds an Investigo contract from Generalitat de Catalunya (100028TC7) and NG was supported by Accio instrumental d'incorporacio de cientifics fi cs i tecnolegs PERIS 2020 (SL017/20/000204) from Generalitat de Catalunya. EC is an Academia Researcher of the "Institucio Catalana de Recerca i Estudis Avancats" (ICREA) of the Generalitat de Catalunya. DWS is supported by a Michael Smith Foundation Research, Health Professional Investigator Award. This work was developed at the Centro Esther Koplowitz, Barcelona, Spain.

Analysis of institutional authors

Mato, SaraAuthorCastrejon-De-Anta, NataliaAuthorColmenero, AriadnaAuthorCarità, LorenzoAuthorSalmeron-Villalobos, JuliaAuthorRamis-Zaldivar, Joan EnricAuthorNadeu, FerranAuthorGarcia, NoeliaAuthorCampo, EliasAuthorBalague, OlgaCorresponding AuthorSalaverria, ItziarCorresponding Author
Share
Publications
>
Article

MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma

Publicated to:Blood Cancer Journal. 14 (1): 171- - 2024-10-07 14(1), DOI: 10.1038/s41408-024-01153-0

Authors: Mato, Sara; Castrejon-de-Anta, Natalia; Colmenero, Ariadna; Carita, Lorenzo; Salmeron-Villalobos, Julia; Ramis-Zaldivar, Joan Enric; Nadeu, Ferran; Garcia, Noelia; Wang, Luojun; Verdu-Amoros, Jaime; Andres, Mara; Conde, Nuria; Celis, Veronica; Ortega, Maria Jose; Galera, Ana; Astigarraga, Itziar; Perez-Alonso, Vanesa; Quiroga, Eduardo; Jiang, Aixiang; Scott, David W; Campo, Elias; Balague, Olga; Salaverria, Itziar

Affiliations

BC Canc Ctr Lymphoid, Vancouver, BC, Canada - Author
Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain - Author
Hosp Clin Barcelona, Hematopathol Sect, Lab Pathol, Barcelona, Spain - Author
Hosp Clin Univ Virgen de la Arrixaca, Pediat Oncohematol Dept, Murcia, Spain - Author
Hosp Clin Univ, Biomed Res Inst INCL Valencia, Pediat Oncol Dept, Valencia, Spain - Author
Hosp La Fe, Pediat Oncol Dept, Valencia, Spain - Author
Hosp St Joan de Deu, Pediat Oncol Dept, Esplugas de Llobregat, Spain - Author
Hosp Univ 12 Octubre, Pediat Oncol Dept, Madrid, Spain - Author
Hosp Univ Cruces Osakidetza, Biocruces Bizkaia Hlth Res Inst, Pediat Oncol Unit, Baracaldo, Spain - Author
Hosp Virgen de las Nieves, Pediat Oncol Dept, Granada, Spain - Author
Hosp Virgen del Rocio, Pediat Oncol Dept, Seville, Spain - Author
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain - Author
Univ Barcelona UB, Barcelona, Spain - Author
Univ British Columbia, Dept Med, Div Med Oncol, Vancouver, BC, Canada - Author
See more

Abstract

Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and a subset of high-grade tumors with features intermediate between these entities whose genetic and molecular profiles have not been completely elucidated. In this study, we have characterized 37 aggressive B-NHL in CAYA, 33 with high-grade morphology, and 4 DLBCL with MYC rearrangement (MYC-R), using targeted next-generation sequencing and the aggressive lymphoma gene expression germinal center B-cell-like (GCB), activated B-cell-like (ABC), and dark zone signatures (DZsig). Twenty-two tumors had MYC-R without BCL2 breaks, and two MYC-non-R cases had BCL6 translocations. MYC-R cases, including DLBCL, carried BL-related mutations and copy number alterations. Conversely, MYC-non-R lymphomas had alterations in the B-cell receptor signaling/NF-kappa B pathway (71%). DZsig was expressed in 12/13 of MYC-R tumors but only in 2/10 of MYC-non-R GCB tumors (P < 0.001). The 3-year event-free survival (EFS) of the whole cohort was 79.6%. TP53 and KMT2C mutations conferred inferior outcome (3-year EFS P < 0.05). Overall, MYC-R lymphomas in CAYA have a molecular profile similar to BL regardless of their high-grade or DLBCL morphology, whereas MYC-non-R has more heterogeneous genetic alterations closer to that of DLBCL.

Keywords
11q aberrationAdolescentAdultArticleAutologous hematopoietic stem cell transplantationB cell lymphomaB lymphocyteBurkitt lymphomaCancer gradingCancer stagingChildChild, preschoolClassificationClinical articleCopy number variationCyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristineDiagnosisDiffuse large b cell lymphomaEvent free survivalFemaleFollow upGene mutationGene rearrangementGeneticsHigh throughput sequencingHigh-resolutionHumanHuman tissueHumansInterferon regulatory factor 4Lactate dehydrogenaseLactate dehydrogenase blood levelLymphoma, large b-cell, diffuseMaleMortalityMutationsMyc proteinMyc protein, humanPathogenesisPathologyPreschool childProto-oncogene proteins c-mycRituximabSox11 expressionSubseTranscription factor sox11Young adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Blood Cancer Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 19/322, thus managing to position itself as a Q1 (Primer Cuartil), in the category Oncology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-09:

  • WoS: 1
  • Scopus: 2
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 18.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.7.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Canada.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mato González, Sara) and Last Author (Salaverria Frigola, Itziar).

the authors responsible for correspondence tasks have been Balagué Ponz, Olga and Salaverria Frigola, Itziar.