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Grant support

This study has been funded by Instituto de Salud Carlos III (ISCIII) through the projects PI18/01005 and PI21/00552, and co-funded by the European Union); the Catalan Pons Balmes Grant (FCRB_PB_2018); and the Government of Catalonia, Secretaria d'Universitats i Recerca del Departament d'Economia I Coneixement (2021 SGR 00672; 2021 SGR 01120).

Analysis of institutional authors

Olivares-Berjaga, DavidAuthorMartinez-Pinteno, AlbertAuthorRodriguez, NataliaAuthorMas, SergiAuthorMoren, ConstanzaAuthorParellada, EduardCorresponding AuthorGasso, PatriciaCorresponding Author

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Review

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Publicated to:Translational Psychiatry. 15 (1): 11- - 2025-01-14 15(1), DOI: 10.1038/s41398-024-03194-2

Authors: Olivares-Berjaga, David; Martinez-Pinteno, Albert; Rodriguez, Natalia; Mas, Sergi; Moren, Constanza; Parellada, Eduard; Gasso, Patricia

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Abstract

Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits. Current antipsychotic drugs ameliorate the positive symptomatology, but are inefficient in treating the negative symptomatology and cognitive deficits. The neurodevelopmental glutamate hypothesis of SZ has opened new avenues in the development of drugs targeting the glutamatergic system. One of these new therapies involves the positive allosteric modulators (PAMs) of metabotropic glutamate receptors, mainly types 2/3 (mGluR2/3). mGluR2/3 PAMs are selective for the receptor, present high tolerability and can modulate the activity of the receptor for long periods. There is not much research in clinical trials regarding mGluR2/3 PAMs. However, several lines of evidence from animal models have indicated the efficiency of mGluR2/3 PAMs. In this review, focusing on in vivo animal studies, we will specifically discuss the utilization of SZ animal models and the various methods employed to assess animal behaviour before summarising the evidence obtained to date in the field of mGluR2/3 PAMs. By doing so, we aim to deepen our understanding of the underlying mechanisms and the potential efficiency of mGluR2/3 PAMs in treating SZ. Overall, mGluR2/3 PAMs have demonstrated efficiency in attenuating SZ-like behavioural and molecular deficits in animal models and could be useful for the early management of the disorder or to treat specific subsets of patients.

Keywords

AgonisAllosteric regulationAnimalsAntipsychotic agentsAntipsychotic-likeDisease models, animalDouble-blindHumansMetabotropic glutamate receptor 2Metabotropic glutamate receptor 3Mouse modelNegative symptomsNmda antagonistPharmacological characterizationPrefrontal cortexReceptors, metabotropic glutamateSchizophreniaSocial memoryWorking-memory

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Translational Psychiatry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 25/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Psychiatry. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-27:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Olivares Berjaga, David) and Last Author (Gassó Astorga, Patricia).

the authors responsible for correspondence tasks have been Parellada Rodon, Eduard and Gassó Astorga, Patricia.