January 30, 2025
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Article

Immigrant Health and Early-Onset Colorectal Cancer Disparities: Results From the Spanish Early-Onset Colorectal Cancer Consortium

Publicated to: Jco Glob Oncol. 10 e2400393- - 2024-12-01 10(), DOI: 10.1200/GO-24-00393

Authors: Perea, J; Martí-Gallostra, M; García-Rodríguez, A; Vidal-Tocino, R; Alcázar, JA; López-Rojo, I; García, SE; Hurtado, E; Jiménez, LM; Alvaro, E; Burdaspal, A; Sanz, G; López, RS; Toscano, MJ; Comas, MI; Jiménez, F; Cavero, A; Balaguer, F; Daca, M; Ballestero, A; Trill, JD; Melone, S; Rueda, JA; Hernández-Villafranca, S; García-Olmo, D; Pastor, C; Alvarellos, A; Brandáriz, L; Viyuela, C; Vivas, A; Muñoz, P; González-Sarmiento, R; Holowatyj, AN

Affiliations

12 Octubre Univ Hosp, Dept Surg, Madrid, Spain - Author
Alcorcon Fdn Hosp, Dept Surg, Madrid, Spain - Author
Clin Univ Hosp, Dept Oncol, Salamanca, Spain - Author
Clin Univ Hosp, Dept Surg, Salamanca, Spain - Author
Fd n Jim enez Diaz Univ Hosp, Dept Surg, Madrid, Spain - Author
Galdakao Usansolo Hosp, Dept Surg, Vizcaya, Spain - Author
Gregorio Maranon Univ Hosp, Dept Surg, Madrid, Spain - Author
Hosp Mar, Dept Surg, Barcelona, Spain - Author
Infanta Leonor Univ Hosp, Dept Pathol, Madrid, Spain - Author
Infanta Leonor Univ Hosp, Dept Surg, Madrid, Spain - Author
Inst Biomed Res Salamanca, Salamanca, Spain - Author
MD Anderson Canc Ctr Madrid, Dept Oncol, Madrid, Spain - Author
MD Anderson Canc Ctr Madrid, Dept Surg, Madrid, Spain - Author
Quironsalud Torrevieja Hosp, Torrevieja, Spain - Author
Ramon & Cajal Univ Hosp, Dept Surg, Madrid, Spain - Author
San Carlos Univ Hosp, Dept Surg, Madrid, Spain - Author
Univ Barcelona, Gastroenterol Dept, Hosp Clin Barcelona, CIBEREHD,IDIBAPS, Barcelona, Spain - Author
Univ Clin Navarra Madrid, Dept Surg, Madrid, Spain - Author
Univ Salamanca, Inst Mol & Cellular Biol Canc IBMCC, SACYL,CSIC, Mol Med Unit,Dept Med,Biomed Res Inst Salamanca I, Salamanca, Spain - Author
Vall dHebr on Univ Hosp, Colorectal Unit, Barcelona, Spain - Author
Vall dHebr on Univ Hosp, Dept Oncol, Barcelona, Spain - Author
Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Med Ctr, Dept Med, Nashville, TN USA - Author
Villalba Univ Hosp, Dept Surg, Madrid, Spain - Author
Vithas Arturo Soria Univ Hosp, Dept Surg, Madrid, Spain - Author
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Abstract

PURPOSE To better understand immigration disparities among a Spanish Early-Onset Colorectal Cancer (SECOC) subset, according to the country of origin. PATIENTS AND METHODS We selected 250 consecutive participants from the SECOC consortium. Data on baseline patient and tumor characteristics, family history of colorectal cancer (CRC), and follow-up were collected. The presence of mismatch repair deficiency was also assessed. Special data regarding country of origin, time of stay in Spain in case of other different country, and a 10-year cutoff that specifies the obtaining of Spanish nationality defined the variables of interest for comparison. RESULTS Seventy-five percent of patients with early-onset CRC (EOCRC) (188) were born in Spain, whereas the other 25% were born outside of Spain. The mean time of living in Spain until the EOCRC diagnosis was 16.5 years. Comparatively, most of the analyzed features showed equivalent proportions between cohorts. Only Spanish patients appeared to have more familial cancer component in first degree in general (32.3%; P = .01), compared with non-Spaniards, which showed a predominant sporadic component (56.4%; P

Keywords

AdultAge of onsetArticleColorectal adenocarcinomaColorectal cancerColorectal neoplasmsColorectal tumorDiagnosisDisease free survivalEarly cancerEmigrants and immigrantsEpidemiologyFamily historyFemaleFollow upGeneticsHereditary tumor syndromeHumanHumansImmigrantImmigrationIncidenceInformed consentMajor clinical studyMaleMedical recordMicrosatellite instabilityMiddle agedMigrantMismatch repairOnset ageOverall survivalPrognostic assessmentRecurrence riskRecurrent diseaseResearch ethicsSocial determinants of healthSpainStatistical analysis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Jco Glob Oncol due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 144/326, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Oncology. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Oncology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-16:

  • WoS: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 4.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions on the social network X (formerly Twitter): 10 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Bladé Creixenti, Joan) .

the author responsible for correspondence tasks has been Bladé Creixenti, Joan.

Awards linked to the item

Supported by Instituto de Salud Carlos III through project PI20/0974 to J.P. (cofunded by European Regional Development Fund "A way to make Europe").