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Grant support

Funded by the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3), PID2023-152918OB-I00 financed by 10.13039/501100011033/FEDER,UE, by ERC, NEMESIS, project number 101071900, and EBRAINS-PREP 101079717 to MVSV. JC was funded by EU Horizon 2020 Marie Sklodowska-Curie grant agreement No 860563.

Analysis of institutional authors

Covelo, JoanaAuthorCamassa, AlessandraAuthorDalla Porta, LeonardoAuthorBosch, MiquelAuthorConde-Blanco, EstefaniaAuthorSanchez-Vives, Maria VCorresponding Author

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February 27, 2025
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Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro

Publicated to:Progress In Neurobiology. 246 102719- - 2025-01-31 246(), DOI: 10.1016/j.pneurobio.2025.102719

Authors: Covelo, Joana; Camassa, Alessandra; Sanchez-Sanchez, Jose Manuel; Manasanch, Arnau; Dalla Porta, Leonardo; Cancino-Fuentes, Nathalia; Barbero-Castillo, Almudena; Robles, Rita M; Bosch, Miquel; Tapia-Gonzalez, Silvia; Merino-Serrais, Paula; Carreno, Mar; Conde-Blanco, Estefania; Arboix, Jordi Rumia; Roldan, Pedro; Defelipe, Javier; Sanchez-Vives, Maria V

Affiliations

CSIC, Inst Cajal, Madrid 28002, Spain - Author
Hosp Clin Barcelona, Unidad Epilepsia, Barcelona 08036, Spain - Author
Inst Biomed Invest August Pi i Sunyer IDIBAPS, Syst Neurosci, Barcelona 08036, Spain - Author
Inst Catalanade Recerca & Estudis Avancats ICREA, Barcelona 08010, Spain - Author
ISCIII, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28029, Spain - Author
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain - Author
Univ Politecn Madrid, Lab Cajal Circuitos Cort, CTB, Madrid 28223, Spain - Author
Univ San Pablo, CEU Univ, Fac Med, Lab Neurofisiol Celular, Madrid, Spain - Author
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Abstract

Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from slices of neocortical tissue from refractory epilepsy patients. Multi-electrode recordings were combined with histological information, providing a two-dimensional spatiotemporal characterization of human cortical dynamics in control conditions and following modulation of the excitation/inhibition balance. Slices expressed spontaneous rhythmic activity consistent with slow wave activity, comprising alternating active (Up) and silent (Down) states (Up-duration: 0.08 +/- 0.03 s, Down-duration: 2.62 +/- 2.12 s, frequency: 0.75 +/- 0.39 Hz). Up states propagated from deep to superficial layers, with faster propagation speeds than in other species (vertical: 64.6 mm/s; horizontal: 65.9 mm/ s). GABAA blockade progressively transformed the emergent activity into epileptiform discharges, marked by higher firing rates, faster network recruitment and propagation, and infraslow rhythmicity (0.01 Hz). This dynamical characterization broadens our understanding of the mechanistic organization of the human cortical network at the micro- and mesoscale.

Keywords

Action potentialsAdultBrainCerebral cortexCortical columnsCortical dynamicCortical dynamicsCortical networkDrug resistant epilepsyEpilepsyEpilepsy surgeryFemaleGranger causalityHumansLess-than-1 hzMaleMembrane-potential fluctuationsNeocortexNerve netNeuronsOscillationPharmacoresistantSleepSlow oscillationsSlow wavesSlow-wave activitySynchronization

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Progress In Neurobiology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 26/310, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-03:

  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 20.6.
  • The number of mentions on the social network X (formerly Twitter): 38 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Covelo Capela, Joana Rita) and Last Author (Sanchez Vives, Maria V.).

the author responsible for correspondence tasks has been Sanchez Vives, Maria V..