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Analysis of institutional authors

Simats, AlbaAuthor

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March 11, 2025
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Systemic inflammation after stroke: implications for post-stroke comorbidities

Publicated to: Embo Molecular Medicine. 14 (9): e16269- - 2022-08-15 14(9), DOI: 10.15252/emmm.202216269

Authors:

Simats, Alba; Liesz, Arthur
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Affiliations

Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany - Author
Munich Cluster Syst Neurol SyNergy, Munich, Germany - Author

Abstract

Immunological mechanisms have come into the focus of current translational stroke research, and the modulation of neuroinflammatory pathways has been identified as a promising therapeutic approach to protect the ischemic brain. However, stroke not only induces a local neuroinflammatory response but also has a profound impact on systemic immunity. In this review, we will summarize the consequences of ischemic stroke on systemic immunity at all stages of the disease, from onset to long-term outcome, and discuss underlying mechanisms of systemic brain-immune communication. Furthermore, since stroke commonly occurs in patients with multiple comorbidities, we will also overview the current understanding of the potential role of systemic immunity in common stroke-related comorbidities, such as cardiac dysfunction, atherosclerosis, diabetes, and infections. Finally, we will highlight how targeting systemic immunity after stroke could improve long-term outcomes and alleviate comorbidities of stroke patients.
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Keywords

Acute ischemic-strokeBrainBrain ischemiaBrain-injuryCardiac complicationsDiabetes-mellituHumansInflammationLong-term outcomeMyocardial-infarctionNeutrophil extracellular trapsNlrp3 inflammasomePost-stroke comorbiditiesRegulatory t-cellsStrokeSympathetic-nervous-systemSystemic immunitSystemic immunityTherapeutic targetTranslational research, biomedical

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EMBO Molecular Medicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 10/136, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 10.51. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-04, the following number of citations:

  • WoS: 103
  • Europe PMC: 67
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 168.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 168 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 30.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Simats Oriol, Alba) .

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Awards linked to the item

This work was funded by the Vascular Dementia Research Foundation, the European Research Council (ERC-StGs 802305) and the German Research Foundation (DFG) under Germany's Excellence Strategy (EXC 2145 SyNergy - ID 390857198), through FOR 2879 (LI-2534/5-1) and under grant SI 2832/1-1 (toAS).
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