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Josep Fuster was supported by an investigation grant from Abertis Infraestructuras S.A.

Analysis of institutional authors

Fuster, JosepCorresponding AuthorHotter, GinaAuthorDeulofeu, RamonAuthorFerrer, JAuthorFerrer, JoanaAuthorFondevila, ConstantinoAuthorCarlos Garcia-Valdecasas, JuanAuthor

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March 12, 2025
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Serum neutrophil gelatinase-associated lipocalin in patients with colorectal liver metastases: preliminary results of an exploratory prospective study

Publicated to:International Journal Of Biological Markers. 25 (1): 21-26 - 2010-01-01 25(1), DOI: 10.1177/172460081002500103

Authors: Marti, Josep; Fuster, Josep; Hotter, Gina; Sola, Anna M; Deulofeu, Ramon; Marta Modolo, Maria; Antonio Loera, Marco; Ferrer, Joana; Fondevila, Constantino; Carlos Garcia-Valdecasas, Juan

Affiliations

Univ Barcelona, Hosp Clin & Prov, CIBERehd, Dept Biochem, E-08036 Barcelona, Spain - Author
Univ Barcelona, Hosp Clin & Prov, Inst Clin Malalties Digest & Metab, Liver Surg & Transplantat Unit,IDIBAPS,CIBERehd, E-08036 Barcelona, Spain - Author
Univ Barcelona, Inst Invest Biomed Barcelona, Dept Ischemia & Inflammat, E-08036 Barcelona, Spain - Author
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Abstract

Purpose: To quantify preoperative serum neutrophil gelatinase-associated lipocalin (NGAL) levels in patients undergoing curative resection of colorectal liver metastases and to assess the relationship between NGAL levels and prognostic features in these patients. Methods: From April 2005 to August 2007, 32 patients operated on for first curative resection of colorectal liver metastases underwent determination of preoperative serum NGAL. Patients were divided into four homogeneous clinical groups and into two risk groups based on their clinical risk scores. NGAL levels were corrected by simultaneous creatinine levels to avoid bias due to renal failure. Results: Higher values of corrected NGAL levels (CNL) were found in patients of the high-risk group (94.53 +/- 56.18 vs 57.87 +/- 24.49, p=0.014). Patients with more than three tumor nodules had higher values of CNL compared to patients with three or fewer nodules (101.78 +/- 56.35 vs 58.57 +/- 27.24, p=0.008). Patients with disease involving both hepatic lobes had higher CNL levels than those with involvement of a single lobe (106.5 +/- 59.13 vs 59.01 +/- 26.69, p=0.005). Patients with higher clinical risk scores had significantly higher CNL. Conclusions: CNL are associated with the considered prognostic clinical factors and scores, suggesting a possible role for CNL as a prognosis-related indicator and a neoplastic tissue volume marker in patients with colorectal liver metastases. (Int Biol Markers 2010; 25: 21-6)

Keywords

AdenocarcinomAgedBloodCancerCarcinomaClinical risk scoreColorectal cancerFemaleHepatic resectionHumansLiver metastasesMaleMiddle agedNatural-historyNeoplastic markerNgalPrognosiPrognosisPrognostic scoring systemProspective studiesRisk factorsSurgical resectionTreatment outcome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Biological Markers due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Oncology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.5, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Nov 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-11-01, the following number of citations:

  • WoS: 9
  • Scopus: 13
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-11-01:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Marti, Josep) and Last Author (García-Valdecasas Salgado, Juan Carlos).

the author responsible for correspondence tasks has been Fuster Obregon, Josep.