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Grant support

Ramon Bataller is a recipient of NIA AA grants U01AA021908 and U01AA020821 from Instituto de Salud Carlos III (PI24/1984) . Edilmar Alvarado-Tapias is a recipient of a Joan Rodes award from the Instituto de Salud Carlos III (JR20/00047) and the PI21/01995 grant from the Instituto de Salud Carlos III-Fondos Feder. Elisa Pose is a recipient of an Instituto de Salud Carlos III grant PI22/00910. Jordi Gratacos-Gines is supported by a Rio Hortega grant, Instituto de Salud Carlos III-Accion Estrategica en Salud, 2021. Ana Clemente-Sanchez is a recipient of a Joan Rodes award from the Instituto de Salud Carlos III (JR23/00080) . Hugo Lopez-Pelayo is a recipient of Red de Investigacion en Atencion Primaria de Adicciones, (RIAPAd (RICORS) ) , which is a project (RD21/0009/0010) funded by the Carlos III Institute, the European Regional Development Fund, and the Recovery, Transformation, and Resilience Plan.r gica en Salud, 2021. Ana Clemente-Sanchez is a recipient of a Joan Rodes award from the Instituto de Salud Carlos III (JR23/00080) . Hugo Lopez-Pelayo is a recipient of Red de Investigacion en Atencion Primaria de Adicciones, (RIAPAd (RICORS) ) , which is a project (RD21/0009/0010) funded by the Carlos III Institute, the European Regional Development Fund, and the Recovery, Transformation, and Resilience Plan.

Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Pose, ElisaAuthorGratacos-Gines, JordiAuthorLopez-Pelayo, HugoAuthorBataller, RamonCorresponding Author

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April 29, 2025
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Alcohol-associated liver disease: Natural history, management and novel targeted therapies

Publicated to:Clinical And Molecular Hepatology. 31 - 2025-02-01 31(), DOI: 10.3350/cmh.2024.0709

Authors: Alvarado-Tapias, Edilmar; Pose, Elisa; Gratacos-Gines, Jordi; Clemente-Sanchez, Ana; Lopez-Pelayo, Hugo; Bataller, Ramon

Affiliations

Autonomus Univ Barcelona, Hosp Santa Creu & St Pau, Dept Gastroenterol & Hepatol, Barcelona, Spain - Author
Ctr Biomed Res Liver & Digest Dis Network CIBERehd, Madrid, Spain - Author
Hosp Clin Barcelona, Inst Invest Biomed August Pi iSunyer IDIBAPS, Liver Unit, Villarroel 170, Barcelona 0836, Catalonia, Spain - Author
Hosp Clin Barcelona, Psychiat & Psychol Serv, Addict Unit, ICN, Barcelona, Spain - Author
Hosp Gen Univ Gregorio Maranon IISGM, Dept Gastroenterol & Hepatol, Madrid, Spain - Author
IDIBAPS, Hlth & Addict Res Grp, Barcelona, Spain - Author
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Abstract

Alcohol consumption is a leading cause of preventable morbidity and mortality worldwide and the primary cause of advanced liver disease. Alcohol use disorder is a chronic, frequently relapsing condition characterized by persistent alcohol consumption despite its negative consequences. Alcohol-associated liver disease (ALD) encompasses a series of stages, from fatty liver (steatosis) to inflammation (steatohepatitis), fibrosis, and, ultimately, liver cirrhosis and its complications. The development of ALD is complex, involving both genetic and environmental factors, yet the exact mechanisms at play remain unclear. Alcohol-associated hepatitis (AH), a severe form of ALD, presents with sudden jaundice and liver failure. Currently, there are no approved targeted therapies able to interfere in the pathogenesis of ALD to stop the progression of the disease, making alcohol abstinence the most effective way to improve prognosis across all stages of ALD. For patients with advanced ALD who do not respond to medical therapy, liver transplantation is the only option that can improve prognosis. Recently, AH has become an early indication for liver transplantation in non-responders to medical treatment, showing promising results in carefully selected patients. This review provides an update on the epidemiology, natural history, pathogenesis, and current treatments for ALD. A deeper insight into novel targeted therapies investigated for AH focusing on new pathophysiologically-based agents is also discussed, including anti-inflammatory and antioxidative stress drugs, gut-liver axis modulators, and hepatocyte regenerative molecules. (Clin Mol Hepatol 2025;31(Suppl):S112-S133)

Keywords

Alcohol use disorderAlcohol-associated hepatitisCirrhosiCorticoidDouble-blindGenome-wide associationHeavy drinkersHepatitis-cLille modelMetabolic syndromeRandomized controlled-trialRisk lociUse disorderZero hunger

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical And Molecular Hepatology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 6/147, thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology & Hepatology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-10-29:

  • WoS: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-29:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 2 - Zero hunger, with a probability of 62% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Bataller Alberola, Ramon).

the author responsible for correspondence tasks has been Bataller Alberola, Ramon.