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This study was sponsored by the Spanish Ministry of Economy and Competitiveness (MINECO PID2020-114640GB-I00/AEI/10.13039/501100011033 and PID2023-146932NB-I00 financed by MICIU/AEI/110.13039/5011000111033/FEDER,UE to C.J. and B.S.), Generalitat de Catalunya (SGR 2021SGR00801) and supported by Maria de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona) CEX2021-001159-M, Ministry of Science and Innovation. I.R. was supported by a fellowship from La Caixa Foundation (LCF/BQ/DR22/11950012). J.P. was supported by a fellowship from the Ministry of Science and Innovation (PRE2021-099674). C.M.B. was supported by Maria de Maeztu Unit of Excellence CEX2021-001159-M/ financed by MICIU/AEI/10.13039/501100011033. J.O. was supported by a fellowship from the Ministry of Science, Innovation, and Universities (PRE2018-086675). The funders played no role in study design, data collection, analysis and interpretation of data, or the writing of this manuscript. We would like to thank the cooperation of patients, their relatives, and healthy control participants. We are indebted to the Magnetic Resonance Imaging core facility of the FRCB-IDIBAPS for technical support. We would also like to acknowledge the CERCA Programme/Generalitat de Catalunya.

Analysis of institutional authors

Roura, IgnacioAuthorPardo, JèssicaAuthorMartin-Barcelo, CristinaAuthorFalcon, CarlesAuthorOltra, JavierAuthorCampabadal, AnnaAuthorBargallo, NuriaAuthorSerradell, MonicaAuthorMaya, GerardAuthorMontini, AngelicaAuthorGaig, CarlesAuthorJunque, CarmeAuthorIranzo, AlexCorresponding AuthorSegura, BarbaraCorresponding Author

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May 6, 2025
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Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD

Publicated to:Npj Parkinsons Dis. 11 (1): 87- - 2025-04-23 11(1), DOI: 10.1038/s41531-025-00942-z

Authors: Roura, Ignacio; Pardo, Jessica; Martin-Barcelo, Cristina; Falcon, Carles; Oltra, Javier; Campabadal, Anna; Bargallo, Nuria; Serradell, Monica; Maya, Gerard; Montini, Angelica; Pont-Sunyer, Claustre; Gaig, Carles; Buongiorno, Mariateresa; Junque, Carme; Iranzo, Alex; Segura, Barbara

Affiliations

Consorci Corp Sanitaria Parc Tauli Sabadell, Neurol Serv, Barcelona, Catalonia, Spain - Author
Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Biomed Imaging Grp, Barcelona, Catalonia, Spain - Author
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Catalonia, Spain - Author
Fundacio Privada Hosp Asil de, Neurol Serv, Movement Disorders Unit, Barcelona, Catalonia, Spain - Author
Hosp Clin Univ Barcelona, Imaging Diagnost Ctr CDI, Barcelona, Catalonia, Spain - Author
Hosp Univ Vall DHebron, Neurol Serv, Barcelona, Catalonia, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Catalonia, Spain - Author
Karolinska Inst, Dept Neurobiol, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden - Author
Stockholm Univ, Stockholm, Sweden - Author
Univ Barcelona, Hosp Clin Univ Barcelona, Neurol Serv, Sleep Unit, Barcelona, Catalonia, Spain - Author
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Catalonia, Spain - Author
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Abstract

Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopathy stage. Furthermore, its associations with clinical symptoms and brain structural abnormalities remain unexplored. We assessed the DTI-ALPS in sixty-two patients with iRBD and twenty-three healthy controls (HC), exploring its associations with clinical symptoms, cortical thickness and brain volumetric data. iRBD patients exhibited a lower DTI-ALPS and poorer odor identification, semantic fluency and processing speed relative to HC. The DTI-ALPS positively correlated with cognitive performance, olfactory function and amygdalar, hippocampal, brainstem and diencephalic volumes, and negatively with age in iRBD. Perivascular glymphatic activity is compromised in iRBD and is associated with brain atrophy and clinical risk factors of progression to alpha-synucleinopathies, supporting the potential of the DTI-ALPS index as an early imaging neurodegeneration marker.

Keywords

Cognitive impairmentCriteriDementiaDiagnosisDiffusionManagementParkinsons-diseaseSleep behavior disorderSymptoms

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NPJ Parkinsons Dis due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 26/310, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences. Notably, the journal is positioned above the 90th percentile.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 4.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 5 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 16.7.
  • The number of mentions on the social network X (formerly Twitter): 18 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Roura Blanco, Ignacio) and Last Author (Segura Fàbregas, Bàrbara).

the authors responsible for correspondence tasks have been Iranzo de Riquer, Alejandro and Segura Fàbregas, Bàrbara.