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Project PI17/00772; Valor de la deteccion del ARNm de los biomarcadores CDKN2A, MKi67, TOP2A en la prevencion secundaria del cancer de cuello de utero, funded by Instituto de Salud Carlos III and co-funded by the European Union (ERDF) A way to make Europe. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

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HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features

Publicado en:American Journal Of Surgical Pathology. 46 (8): 1071-1077 - 2022-08-01 46(8), DOI: 10.1097/pas.0000000000001885

Autores: Guerrero, Jose; Trias, Isabel; Veloza, Luis; del Pino, Marta; Garcia, Adriana; Marimon, Lorena; Diaz-Mercedes, Sherley; Rodrigo-Calvo, Maria T; Alos, Silvia; Ajami, Tarek; Parra-Medina, Rafael; Martinez, Antonio; Reig, Oscar; Ribal, Maria J; Corral-Molina, Juan M; Ordi, Jaume; Ribera-Cortada, Inmaculada; Rakislova, Natalia

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Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83?y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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