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Rovira, MontserratAutor o Coautor

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Younger unrelated donors may be preferable over HLA match in the PTCy era: a study from the ALWP of the EBMT

Publicado en:Blood. 143 (24): 2534-2543 - 2024-06-13 143(24), DOI: 10.1182/blood.2023023697

Autores: Sanz, Jaime; Labopin, Myriam; Choi, Goda; Kulagin, Alexander; Peccatori, Jacopo; Vydra, Jan; Remenyi, Peter; Versluis, Jurjen; Rovira, Montserrat; Blaise, Didier; Labussiere-Wallet, Helene; Montoro, Juan; Sica, Simona; Meijer, Ellen; Itala-Remes, Maija; Schaap, Nicolaas; Bulabois, Claude Eric; Piemontese, Simona; Mohty, Mohamad; Ciceri, Fabio

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There is a paucity of information on how to select the most appropriate unrelated donor (UD) in hematopoietic stem cell transplantation (HSCT) using posttransplant cyclophosphamide (PTCy). We retrospectively analyzed the characteristics of 10/10 matched UDs (MUDs) and 9/10 mismatched UDs (MMUDs) that may affect transplant outcomes in patients with acute myeloid leukemia (AML) in fi rst or second complete remission (CR1 or CR2). The primary end point was leukemia-free survival (LFS). Overall, 1011 patients were included with a median age of 54 years (range, 18-77). Donors had a median age of 29 years (range, 18-64); 304 (30%) were females, of which 150 (15% of the whole group) were donors to male recipients, and 621 (61%) were MUDs; 522 (52%) had negative cytomegalovirus (CMV -neg) serostatus, of which 189 (19%) were used for CMV -neg recipients. Donor age older than 30 years had a negative impact on relapse (hazard ratio [HR], 1.38; 95% con fi dence interval [CI], 1.06-1.8), LFS (HR, 1.4; 95% CI, 1.12-1.74), overall survival (HR 1.45; 95% CI, 1.14-1.85) and graft-versus-host disease (GVHD) free, relapse-free survival (HR, 1.29; 95% CI, 1.07-1.56). In addition, CMV -neg donors for CMV -neg recipients were associated with improved LFS (HR, 0.74; 95% CI, 0.55-0.99). The use of MMUD and female donors for male recipients did not signi fi cantly impact any transplant outcomes. For patients undergoing HSCT from a UD with PTCy for AML, donor age

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