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3 This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 796706, and the Instituto de Salud Carlos III (ISCIII) grant PI19/00335 Accion Estrategica en Salud, integrated in the Spanish National R+D+I Plan and financed by ISCIII-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-Una manera de hacer Europa) awarded to M.M.

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Association between retinal thickness and beta-amyloid brain accumulation in individuals with subjective cognitive decline: Fundacio ACE Healthy Brain Initiative

Publicat a:Alzheimers Research & Therapy. 12 (1): 37- - 2020-03-31 12(1), DOI: 10.1186/s13195-020-00602-9

Autors: Marquie, Marta; Valero, Sergi; Castilla-Marti, Miguel; Martinez, Joan; Rodriguez-Gomez, Octavio; Sanabria, Angela; Pablo Tartari, Juan; Monte-Rubio, Gemma C; Sotolongo-Grau, Oscar; Alegret, Montserrat; Perez-Cordon, Alba; Roberto, Natalia; de Rojas, Itziar; Moreno-Grau, Sonia; Montrreal, Laura; Hernandez, Isabel; Rosende-Roca, Maitee; Mauleon, Ana; Vargas, Liliana; Abdelnour, Carla; Gil, Silvia; Esteban-De Antonio, Ester; Espinosa, Ana; Ortega, Gemma; Lomena, Francisco; Pavia, Javier; Vivas, Assumpta; Angel Tejero, Miguel; Gomez-Chiari, Marta; Simo, Rafael; Ciudin, Andreea; Hernandez, Cristina; Orellana, Adelina; Benaque, Alba; Ruiz, Agustin; Tarraga, Lluis; Boada, Merce

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Background: Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-beta (A beta) uptake. Aims: We investigated the association of retinal thickness quantified by OCT with A beta accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. Methods: One hundred twenty-nine individuals with SCD enrolled in Fundacio ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/-) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Results: Mean age of the sample was 64.72 +/- 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 mu m of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02-1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: beta = 0.23, p = 0.004; at v2: beta = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Conclusions: Subtle retinal thickness changes in the macular region are already present in SCD and correlate with A beta uptake.

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