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3 This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 796706, and the Instituto de Salud Carlos III (ISCIII) grant PI19/00335 Accion Estrategica en Salud, integrated in the Spanish National R+D+I Plan and financed by ISCIII-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-Una manera de hacer Europa) awarded to M.M.

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Campos Añón, FranciscoAuthorRoberto, NataliaAuthor

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March 31, 2021
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Association between retinal thickness and beta-amyloid brain accumulation in individuals with subjective cognitive decline: Fundacio ACE Healthy Brain Initiative

Publicated to:Alzheimers Research & Therapy. 12 (1): 37- - 2020-03-31 12(1), DOI: 10.1186/s13195-020-00602-9

Authors: Marquie, Marta; Valero, Sergi; Castilla-Marti, Miguel; Martinez, Joan; Rodriguez-Gomez, Octavio; Sanabria, Angela; Pablo Tartari, Juan; Monte-Rubio, Gemma C; Sotolongo-Grau, Oscar; Alegret, Montserrat; Perez-Cordon, Alba; Roberto, Natalia; de Rojas, Itziar; Moreno-Grau, Sonia; Montrreal, Laura; Hernandez, Isabel; Rosende-Roca, Maitee; Mauleon, Ana; Vargas, Liliana; Abdelnour, Carla; Gil, Silvia; Esteban-De Antonio, Ester; Espinosa, Ana; Ortega, Gemma; Lomena, Francisco; Pavia, Javier; Vivas, Assumpta; Angel Tejero, Miguel; Gomez-Chiari, Marta; Simo, Rafael; Ciudin, Andreea; Hernandez, Cristina; Orellana, Adelina; Benaque, Alba; Ruiz, Agustin; Tarraga, Lluis; Boada, Merce

Affiliations

Clin Corachan, Dept Diagnost Imaging, Barcelona, Spain - Author
Clin Oftalmol Dr Castilla, Barcelona, Spain - Author
Hosp Esperanza, Parc Salut Mar, Barcelona, Spain - Author
Hosp Mar, Dept Ophthalmol, Parc Salut Mar, Barcelona, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain - Author
UAB, VHIR, Inst Recerca Vall dHebron, Barcelona, Spain - Author
UIC, Fundacio ACE Inst Catala Neurociencies Aplicades, Memory Clin, Gran Via Carles 3,85 Bis, Barcelona 08028, Spain - Author
UIC, Fundacio ACE Inst Catala Neurociencies Aplicades, Res Ctr, Gran Via Carles 3,85 Bis, Barcelona 08028, Spain - Author
Univ Barcelona, Hosp Clin & Prov Barcelona, Dept Radiol, Barcelona, Spain - Author
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Abstract

Background: Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-beta (A beta) uptake. Aims: We investigated the association of retinal thickness quantified by OCT with A beta accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. Methods: One hundred twenty-nine individuals with SCD enrolled in Fundacio ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/-) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Results: Mean age of the sample was 64.72 +/- 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 mu m of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02-1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: beta = 0.23, p = 0.004; at v2: beta = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Conclusions: Subtle retinal thickness changes in the macular region are already present in SCD and correlate with A beta uptake.

Keywords

Alzheimers-diseaseBeta-amyloidDegenerationDementiaFlorbetabenImpairmentMemory complaintsMini-mental stateNational instituteOptical coherence tomographyPositron emission tomographyPrevalenceRetinal thicknessSubjective cognitive declineValidationΒ-amyloid

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Alzheimers Research & Therapy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 21/208, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.76. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 9.52 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-21, the following number of citations:

  • WoS: 30

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 78.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 81 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.