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Puig Butille, Joan AntonAutor o coautorMolina, RAutor o coautorPuig, SAutor o coautorConill, CAutor o coautorVera, MAutor o coautorAuge, JmAutor o coautorMalvehy, JAutor o coautorGrau, JjAutor o coautorGascon, PAutor o coautorMellado, BAutor o coautor

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Serum protein S-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon -: Comparison with tyrosinase RT-PCR

Publicat a:Oncology. 68 (4-6): 341-349 - 2005-01-01 68(4-6), DOI: 10.1159/000086973

Autors: Domingo-Domènech, J; Molina, R; Castel, T; Montagut, C; Puig, S; Conill, C; Martí, R; Vera, M; Auge, JM; Malvehy, J; Grau, JJ; Gascon, P; Mellado, B

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Objective: To study the clinical value of the determination of serum S-100 protein as a single tumor marker or in combination with tyrosinase RT-PCR in patients with melanoma receiving adjuvant interferon. Patients and Methods: Patients were tested for serum S-100 protein luminoimmunometric assay and for blood tyrosinase mRNA (RT-PCR), before starting interferon and every 23 months thereafter. Results: One hundred and six patients (stage IIA, 27; IIB, 19; III, 49; and IV, 11) were included in the study. Median follow-up was 51 months (range 2-76). In the univariate analysis, under treatment S-100 >= 0.15 mu g/l and a positive RT-PCR correlated with a lower disease-free survival and overall survival (OS). In the multivariate analysis, clinical stage, under therapy positive RT-PCR and S-100 levels >= 0.15 mu g/ml, were independent prognostic factors for OS. The hazard ratio for OS was 3.9 (95% Cl, 1.7-9.115; p = 0.004) and 2.2 (95% Cl, 1.05-4.6; p = 0.016) for S-100 >= 0.15 mu g/l and positive RT-PCR, respectively. When both techniques where combined, a positive RT-PCR indicated a poorer clinical outcome only in patients with S-100= 0.15 mu g/l and a positive RT-PCR during adjuvant interferon therapy indicate a high risk of death in resected melanoma patients. S-100 determination has a higher positive predictive value than RT-PCR, while tyrosinase RT-PCR adds prognostic information in patients with S-100

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