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Analysis of institutional authors

Puig Butille, Joan AntonAuthorMolina, RAuthorPuig, SAuthorConill, CAuthorVera, MAuthorAuge, JmAuthorMalvehy, JAuthorGrau, JjAuthorGascon, PAuthorMellado, BAuthor
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Serum protein S-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon -: Comparison with tyrosinase RT-PCR

Publicated to:Oncology. 68 (4-6): 341-349 - 2005-01-01 68(4-6), DOI: 10.1159/000086973

Authors: Domingo-Domènech, J; Molina, R; Castel, T; Montagut, C; Puig, S; Conill, C; Martí, R; Vera, M; Auge, JM; Malvehy, J; Grau, JJ; Gascon, P; Mellado, B

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Abstract

Objective: To study the clinical value of the determination of serum S-100 protein as a single tumor marker or in combination with tyrosinase RT-PCR in patients with melanoma receiving adjuvant interferon. Patients and Methods: Patients were tested for serum S-100 protein luminoimmunometric assay and for blood tyrosinase mRNA (RT-PCR), before starting interferon and every 23 months thereafter. Results: One hundred and six patients (stage IIA, 27; IIB, 19; III, 49; and IV, 11) were included in the study. Median follow-up was 51 months (range 2-76). In the univariate analysis, under treatment S-100 >= 0.15 mu g/l and a positive RT-PCR correlated with a lower disease-free survival and overall survival (OS). In the multivariate analysis, clinical stage, under therapy positive RT-PCR and S-100 levels >= 0.15 mu g/ml, were independent prognostic factors for OS. The hazard ratio for OS was 3.9 (95% Cl, 1.7-9.115; p = 0.004) and 2.2 (95% Cl, 1.05-4.6; p = 0.016) for S-100 >= 0.15 mu g/l and positive RT-PCR, respectively. When both techniques where combined, a positive RT-PCR indicated a poorer clinical outcome only in patients with S-100= 0.15 mu g/l and a positive RT-PCR during adjuvant interferon therapy indicate a high risk of death in resected melanoma patients. S-100 determination has a higher positive predictive value than RT-PCR, while tyrosinase RT-PCR adds prognostic information in patients with S-100

Keywords
AdolescentAdultAgedAntineoplastic agentsBiomarkers, tumorBloodCancerChemotherapy, adjuvantCooperative-oncology-groupCutaneous melanomaDose interferon-alpha-2bFemaleHigh-risk melanomaHumansInterferon alpha-2Interferon-alphaMaleMelanomaMessenger-rnaMetabolismMetastatic malignant-melanomaMiddle agedMonophenol monooxygenaseNeoplasm stagingPeripheral-bloodPolymerase-chain-reactionPredictive value of testsPrognostic-significanceRecombinant proteinsReverse transcriptase polymerase chain reactionRna, messengerRna, neoplasmS-100S100 proteinsS100b proteiSkin neoplasmsSpainTyrosinase reverse transcription-polymerase chain reactioTyrosinase reverse transcription-polymerase chain reaction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Oncology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2005, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.7, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-12, the following number of citations:

  • WoS: 17
  • Scopus: 18
  • Europe PMC: 11
  • Google Scholar: 18
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-12:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Domingo-Domenech, J) and Last Author (Mellado González, Begoña).

the author responsible for correspondence tasks has been Domingo-Domenech, J.