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Grant support

This work was supported by grants from Instituto de Salud Carlos III [grant number PI11/00051, PI12/00801], from the Ministerio de Economia y Competitividad [grant number SAF2012-37196], cofinanced by the Fondo Europeo de Desarrollo Regional de la Union Europea Una manera de hacer Europa, Fundacion Mutua Madrilena, Obra Social la Caixa, Fundacio Agrupacio Mutua (Spain) and Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK). B.V.A. was supported by Programa de Ayudas Predoctorales FI Agaur (2013FI_B 00667) and wishes to express her gratitude to the Mexican National Council of Science and Technology (CONACyT, Mexico City, Mexico) for partially supporting her predoctoral stay at Hospital Clinic, Barcelona, Spain.

Analysis of institutional authors

Valenzuela-Alcaraz, BAuthorCrispi, FAuthorManau, DAuthorCruz-Lemini, MAuthorBorras, AAuthorBalasch, JAuthorGratacos, ECorresponding Author

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Article

Differential effect of mode of conception and infertility treatment on fetal growth and prematurity

Publicated to:Journal Of Maternal-Fetal & Neonatal Medicine. 29 (23): 3879-3884 - 2016-01-01 29(23), DOI: 10.3109/14767058.2016.1151868

Authors: Valenzuela-Alcaraz, Brenda; Crispi, Fatima; Manau, Dolors; Cruz-Lemini, Monica; Borras, Aina; Balasch, Juan; Gratacos, Eduard

Affiliations

Ctr Biomed Res Rare Dis CIBER ER, Barcelona, Spain - Author
Univ Barcelona, Hosp Clin, Barcelona Ctr Maternal Fetal & Neonatal Med, BCNatal, Barcelona, Spain - Author
Univ Barcelona, IDIBAPS, Infertil & Assited Reprod Unit, Fac Med,Hosp Clin, Barcelona, Spain - Author
Univ Barcelona, Inst Invest Biomed August Pi I Sunyer, Hosp St Joan De Deu, Barcelona, Spain - Author

Abstract

Objectives To examine perinatal outcomes in pregnancies conceived by different methods: fertile women with spontaneous pregnancies, infertile women who achieved pregnancy without treatment, pregnancies achieved by ovulation induction (OI) and in vitro fertilization or intra-cytoplasmic sperm injection (IVF/ICSI). Methods Retrospective single-center cohort study including 200 fertile and 748 infertile women stratified according to infertility treatment. The outcome measurements were preterm delivery (PTD), small-for-gestational-age (SGA), gestational diabetes, placenta previa or preeclampsia. Results The overall rate of pregnancy complications was significantly increased in all infertility groups regardless of the infertility treatment (adjusted odds ratio (OR): infertile without treatment 2.3 versus OI 2.2 versus IVF/ICSI 3.4). While PTD was mainly associated to IVF/ICSI (adjusted OR: infertile without treatment 1.3 versus OI 1.6 versus IVF/ICSI 3.3), SGA was significantly associated to both OI and IVF/ICSI (adjusted OR: infertile without treatment 1.9 versus OI 2.7 versus IVF/ICSI 2.6). All these associations remained statistically significant after adjusting by maternal age and twin pregnancy. Conclusions This study confirms the higher prevalence of pregnancy complications in infertile women irrespectively of receiving infertility treatment or not, and further describes a preferential association of prematurity with IVF/ICSI, and SGA with treated infertility (OI and IVF/ICSI).

Keywords

assisted reproductive technologiesassisted reproductive technologyincreased riskintrauterine growth restrictionlow birth weightlow-birth-weightmetaanalysisperinatal outcomeperinatal outcomespregnanciespreterm deliverysingletonssmall for gestational agestimulationAdultAnalysis of varianceAssisted reproductive technologiesCase-control studiesFemaleFertilization in vitroFetal developmentHumansIn-vitro fertilizationInfant, newbornInfant, prematureInfant, small for gestational ageInfertility, femaleIntrauterine growth restrictionLow birth weightMaleOvulation inductionPerinatal outcomePregnancyPregnancy complicationsPregnancy outcomePregnancy, high-riskPremature birthRetrospective studiesSmall for gestational ageSperm injections, intracytoplasmic

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Maternal-Fetal & Neonatal Medicine due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Pediatrics, Perinatology and Child Health. Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Obstetrics & Gynecology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 5.21, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-15, the following number of citations:

  • WoS: 16
  • Scopus: 18
  • Europe PMC: 9
  • OpenCitations: 16

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 57.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 57 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.5.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Valenzuela Alcaraz, Brenda Iveth) and Last Author (Gratacós Solsona, Eduard).

the author responsible for correspondence tasks has been Gratacós Solsona, Eduard.