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Analysis of institutional authors

Soriano AAuthorBermudo RAuthorAlonso IAuthorBlanco JAuthorMunoz MAuthorFernandez PCorresponding Author

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Article

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells

Publicated to:Oncotarget. 8 (48): 83384-83406 - 2017-10-13 8(48), DOI: 10.18632/oncotarget.20698

Authors: Sanchez-Cid, Lourdes; Pons, Monica; Jose Lozano, Juan; Rubio, Nuria; Guerra-Rebollo, Marta; Soriano, Aroa; Paris-Coderch, Laia; Segura, Miquel F; Fueyo, Raquel; Arguimbau, Judit; Zodda, Erika; Bermudo, Raquel; Alonso, Immaculada; Caparros, Xavier; Cascante, Marta; Rafii, Arash; Kang, Yibin; Martiez-Balbas, Marian; Weiss, Stephen J; Blanco, Jeronimo; Munoz, Montserrat; Fernandez, Pedro L; Thomson, Timothy M

Affiliations

Hosp Clin Barcelona, Dept Obstet & Gynecol, Barcelona, Spain      Hospital Clinic de Barcelona    University of Barcelona - Author
Hosp Clin Barcelona, Dept Oncol, Barcelona, Spain      Hospital Clinic de Barcelona    University of Barcelona - Author
Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain.      Hospital Clinic de Barcelona    University of Barcelona - Author
Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain      Hospital Clinic de Barcelona    University of Barcelona - Author
Inst Adv Chem Catalonia IQAC CSIC, Barcelona, Spain      CSIC - Instituto de Quimica Avanzada de Cataluna (IQAC)    Consejo Superior de Investigaciones Cientificas (CSIC) - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.      IDIBAPS    Hospital Clinic de Barcelona    University of Barcelona - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain      IDIBAPS    University of Barcelona    Hospital Clinic de Barcelona - Author
Inst Salud Carlos III, Networked Biomed Res Ctr Bioengn Biomat & Nanomed, Madrid, Spain      Instituto de Salud Carlos III - Author
Inst Salud Carlos III, Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Madrid, Spain      CIBER - Centro de Investigacion Biomedica en Red    Instituto de Salud Carlos III    CIBERES    CIBEREHD - Author
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA      Princeton University - Author
Spanish Natl Res Council IBMB CSIC, Inst Mol Biol, Barcelona, Spain - Author
Univ Autonoma Barcelona, Vall Hebron Inst Recerca VHIR, Barcelona, Spain      Vall d'Hebron Institut de Recerca (VHIR)    Hospital Universitari Vall d'Hebron    Autonomous University of Barcelona    Catalan Health Institute - Author
Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, Barcelona, Spain      University of Barcelona - Author
Univ Barcelona, Sch Med, Barcelona, Spain.      University of Barcelona - Author
Univ Barcelona, Sch Med, Barcelona, Spain      University of Barcelona - Author
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA      University of Michigan    University of Michigan System - Author
Weill Cornell Med Coll, Ar Rayyan, Qatar      Weill Cornell Medical College Qatar - Author
       - Author
      Spanish Natl Res Council IBMB CSIC, Inst Mol Biol, Barcelona, Spain. - Author
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Abstract

MicroRNAs are critical regulators of gene networks in normal and abnormal biological processes. Focusing on invasive ductal breast cancer (IDC), we have found dysregulated expression in tumor samples of several microRNAs, including the miR-200 family, along progression from primary tumors to distant metastases, further reflected in higher blood levels of miR-200b and miR-7 in IDC patients with regional or distant metastases relative to patients with primary node-negative tumors. Forced expression of miR-200s in MCF10CA1h mammary cells induced an enhanced epithelial program, aldehyde dehydrogenase (ALDH) activity, mammosphere growth and ability to form branched tubuloalveolar structures while promoting orthotopic tumor growth and lung colonization in vivo. MiR-200s also induced the constitutive activation of the PI3K-Akt signaling through downregulation of PTEN, and the enhanced mammosphere growth and ALDH activity induced in MCF10CA1h cells by miR-200s required the activation of this signaling pathway. Interestingly, the morphology of tumors formed in vivo by cells expressing miR-200s was reminiscent of metaplastic breast cancer (MBC). Indeed, the epithelial components of MBC samples expressed significantly higher levels of miR-200s than their mesenchymal components and displayed a marker profile compatible with luminal progenitor cells. We propose that microRNAs of the miR-200 family promote traits of highly proliferative breast luminal progenitor cells, thereby exacerbating the growth and metastatic properties of transformed mammary epithelial cells.

Keywords

activationcarcinomasdeterminesepithelial reprogramminginvasive ductal breast cancermaintenancemarkersmesenchymal transitionmicrornasmir-200pluripotencyprecursorsprogenitor luminal cellsviabilityBreast cancerCáncer de mamaCèl·lules epitelialsEpithelial cellsEpithelial reprogrammingInvasive ductal breast cancerMicro rnasMicrornasMir-200Progenitor luminal cellsStem-cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Oncotarget due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Oncology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.65, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-30, the following number of citations:

  • WoS: 24
  • Scopus: 26
  • Europe PMC: 12

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 53.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 53 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/127217

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Qatar; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Sánchez-Cid L) .

the author responsible for correspondence tasks has been Fernandez Ruiz, Pedro Luis.