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Analysis of institutional authors

Coll Loperena, Maria Del MarOthersColl Miro, MarinaAuthorChavarria Vilarasau, LaiaAuthorBlaya, DAuthorAguilar-Bravo, BAuthorPerea, LAuthorVallverdu, JAuthorGraupera, IAuthorPose, EAuthorCubero, FjAuthorCaballeria, JAuthorGines, PCorresponding Author

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November 22, 2018
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Expression of microRNA-155 in inflammatory cells modulates liver injury

Publicated to: Hepatology. 68 (2): 691-706 - 2018-08-01 68(2), DOI: 10.1002/hep.29833

Authors:

Blaya, Delia; Aguilar-Bravo, Beatriz; Hao, Fengjie; Casacuberta-Serra, Silvia; Coll, Mar; Perea, Luis; Vallverdu, Julia; Graupera, Isabel; Pose, Elisa; Llovet, Laura; Barquinero, Jordi; Javier Cubero, Francisco; Caballeria, Juan; Gines, Pere; Sancho-Bru, Pau
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Affiliations

12 Octubre Hlth Res Inst Imas12, Madrid, Spain - Author
CIBEREHD, Barcelona, Spain      CIBEREHD    CIBER - Centro de Investigacion Biomedica en Red - Author
Hosp Clin Barcelona, Liver Unit, Barcelona, Spain      University of Barcelona    Hospital Clinic de Barcelona - Author
IDIBAPS, C Rossello 149-153, Barcelona 08036, Spain.      IDIBAPS    University of Barcelona    Hospital Clinic de Barcelona - Author
IDIBAPS, Lab Liver Cell Plast & Tissue Repair, Barcelona, Spain      University of Barcelona    Hospital Clinic de Barcelona    IDIBAPS - Author
Univ Complutense Madrid, Dept Immunol, Sch Med, Madrid, Spain      Complutense University of Madrid       - Author
Vall dHebron Inst Recerca, Gene & Cell Therapy Lab, Barcelona, Spain      Catalan Health Institute    Autonomous University of Barcelona    Vall d'Hebron Institut de Recerca (VHIR)    Hospital Universitari Vall d'Hebron - Author
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Abstract

© 2018 by the American Association for the Study of Liver Diseases. MicroRNA 155 (miR-155) is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR-155 regulation of liver injury are largely unknown. The role of miR-155 in acute liver injury was assessed in wild-type (WT), miR-155-/-, and miR-155-/-mice transplanted with WT bone marrow. Additionally, miR-155 expression was evaluated in liver tissue and peripheral blood mononuclear cells of patients with autoimmune hepatitis. Concanavalin A, but not acetaminophen, treatment increased the expression of miR-155 in liver tissue of WT mice. Concanavalin A induced increases in cell death, liver aminotransferases, and expression of proinflammatory cytokines (chemokine [C-X-C motif] ligands 1, 5, 9, 10, and 11; chemokine [C-C motif] ligands 2 and 20; and intercellular cell adhesion molecule 1) in miR-155-/-compared to WT mice. Importantly, these animals showed a significant decrease in cluster of differentiation 4-positive/chemokine (C-X-C motif) receptor 3-positive and forkhead box p3-positive cell recruitment but no changes in other inflammatory cell populations. Mechanistically, miR-155-deficient regulatory T cells showed increased SH2 domain-containing inositol 5-phosphatase 1 expression, a known target of miR-155. Inhibition of SH2 domain-containing inositol 5-phosphatase 1 in miR-155-/-mice restored forkhead box p3 recruitment and reduced liver cytokine expression. Transplantation of bone marrow from WT animals into miR-155-/-mice partially reversed the effect of concanavalin A on miR-155-/-mice as assessed by proinflammatory cytokines and cell death protein expression. Patients with autoimmune hepatitis showed a marked increase in miR-155 expression in the liver but reduced expression of miR-155 in peripheral blood mononuclear cells. Conclusion: miR-155 expression is altered in both liver tissue and circulating inflammatory cells during liver injury, thus regulating inflammatory cell recruitment and liver damage; these results suggest that maintaining miR-155 expression in inflammatory cells might be a potential strategy to modulate liver injury. (Hepatology 2018).
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Keywords

alcoholic hepatitisdifferentiationimmune functionmechanismsmediated regulationmicemir-155regulatory t-cellsshipAcute liver injuryAdultAgedAnimalsConaConcanavalin aConcanavalin-a modelCytokinesFemaleHepatitis, autoimmuneHepatocytesHumansLiverLiver diseasesLiver inflammationMaleMiceMice, knockoutMicrornasMiddle agedMirn155 microrna, humanMirn155 microrna, mouseShip1Signal transductionTregs

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal HEPATOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 5/84, thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology & Hepatology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.99. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-05, the following number of citations:

  • WoS: 62
  • Scopus: 43
  • Europe PMC: 54
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 68.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 68 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Blaya Diez de Revenga, Delia) and Last Author (Sancho Bru, Pau).

the authors responsible for correspondence tasks have been Sancho Bru, Pau and Sancho-Bru, Pau.

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