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Analysis of institutional authors

Haddad Tovolli, RobertaAuthorGarcia, AliciaAuthorObri AAuthorEyre Sánchez, ElenaAuthorChivite IAuthorMilà-Guasch MAuthorRamirez SAuthorPozo MAuthorClaret MCorresponding Author

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Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Publicated to:Molecular Metabolism. 36 100963- - 2020-06-01 36(), DOI: 10.1016/j.molmet.2020.02.006

Authors: Haddad-Tovolli, Roberta; Altirriba, Jordi; Obri, Arnaud; Eyre Sanchez, Elena; Chivite, Inigo; Mila-Guasch, Maria; Ramirez, Sara; Gomez-Valades, Alicia G; Pozo, Macarena; Burguet, Jasmine; Velloso, Licio A; Claret, Marc

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Abstract

© 2020 The Authors Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms remain largely unknown. In this study we sought to determine the translatomic signatures associated with pro-opiomelanocortin (POMC) neuron malprogramming in maternal obesogenic conditions. Methods: We used the RiboTag mouse model to specifically profile the translatome of POMC neurons during neonatal (P0) and perinatal (P21) life and its neuroanatomical, functional, and physiological consequences. Results: Maternal high-fat diet (HFD) exposure did not interfere with offspring's hypothalamic POMC neuron specification, but significantly impaired their spatial distribution and axonal extension to target areas. Importantly, we established POMC neuron-specific translatome signatures accounting for aberrant neuronal development and axonal growth. These anatomical and molecular alterations caused metabolic dysfunction in early life and adulthood. Conclusions: Our study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts.

Keywords

cytoscapeenvironmentidentityleptinmouseneuronal programmingobesitypackagepomc neuronribotagrnasoftwaretranslatomeAnimalsCytoscapeDiet, high-fatDnaDna methylationEnvironmentFemaleGenome-wide association studyHypothalamic melanocortin neuronsHypothalamusIdentityLeptinMaleMiceMouseNeurogenesisNeuronal programmingNeuronsObesityPackagePomc neuronPregnancyPrenatal exposure delayed effectsPro-opiomelanocortinRibotagRnaSoftwareTranslatome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecular Metabolism due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 16/146, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.62, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-30, the following number of citations:

  • WoS: 11
  • Scopus: 12
  • Europe PMC: 9
  • OpenCitations: 11

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 42.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 42 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.4.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 22 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil; France; Switzerland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Haddad-Tóvolli R) and Last Author (Claret Carles, Marc).

the authors responsible for correspondence tasks have been Haddad-Tóvolli R and Claret Carles, Marc.