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Coll Loperena, Maria Del MarAuthorChavarria Vilarasau, LaiaAuthorColl M.Author
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Review

Physiopathology of splanchnic vasodilation in portal hypertension

Publicated to:World Journal Of Hepatology. 2 (6): 208-220 - 2010-06-27 2(6), DOI: 10.4254/wjh.v2.i6.208

Authors: Martell M; Coll M; Ezkurdia N; Raurell I; Genescà J

Affiliations

Hospital Universitari Vall d'Hebron - Author
Univ Autonoma Barcelona, Inst Recerca, Hosp Univ Vall dHebron, Liver Dis Lab,Liver Unit,Dept Internal Med, Barcelona 08035, Spain - Author

Abstract

In liver cirrhosis, the circulatory hemodynamic alterations of portal hypertension significantly contribute to many of the clinical manifestations of the disease. In the physiopathology of this vascular alteration, mesenteric splanchnic vasodilation plays an essential role by initiating the hemodynamic process. Numerous studies performed in cirrhotic patients and animal models have shown that this splanchnic vasodilation is the result of an important increase in local and systemic vasodilators and the presence of a splanchnic vascular hyporesponsiveness to vasoconstrictors. Among the molecules and factors known to be potentially involved in this arterial vasodilation, nitric oxide seems to have a crucial role in the physiopathology of this vascular alteration. However, none of the wide variety of mediators can be described as solely responsible, since this phenomenon is multifactorial in origin. Moreover, angiogenesis and vascular remodeling processes also seem to play a role. Finally, the sympathetic nervous system is thought to be involved in the pathogenesis of the hyperdynamic circulation associated with portal hypertension, although the nature and extent of its role is not completely understood. In this review, we discuss the different mechanisms known to contribute to this complex phenomenon. © 2010 Baishideng.

Keywords
bacterial translocationcapsaicin treatmentcirrhotic rat-liverendothelial dysfunctionhepatic stellate cellshyperdynamic circulationliver cirrhosisportal hypertensionsmooth-musclesplanchnic vasodilationsuperior mesenteric-arteriessympathetic nervous systemvascular adrenergic-nervesHyperdynamic circulationLiver cirrhosisNitric-oxide synthasePortal hypertensionSplanchnic vasodilationSympathetic nervous system

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal World Journal Of Hepatology, Q4 Agency Scopus (SJR), its regional focus and specialization in Hepatology, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 13.65, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Apr 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-04-25, the following number of citations:

  • WoS: 147
  • Scopus: 90
  • Europe PMC: 57
  • Google Scholar: 163
  • OpenCitations: 95
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 166.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 166 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.072.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.