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Ramirez Mahaluf, Juan PabloAuthorLi Bassi, GianluigiAuthorMotos AAuthorBassi GlAuthorYang HAuthorYang MAuthorBobi JAuthorFrigola GAuthorFernández-Barat LAuthorRigol, MAuthorRamírez JAuthorArtigas AAuthorGuerrero LAuthorSoy DAuthorTorres ACorresponding Author

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October 21, 2020
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Article

Efficacy of telavancin in comparison to linezolid in a porcine model of severe methicillin-resistant Staphylococcus aureus (MRSA) pneumonia

Publicated to: Antimicrobial Agents And Chemotherapy. 65 (1): e01009-20- - 2021-01-01 65(1), DOI: 10.1128/aac.01009-20

Authors:

Battaglini, D; Motos, A; Li Bassi, G; Yang, H; Pagliara, F; Yang, M; Xiol, EA; Meli, A; Bobi, J; Frigola, G; Senussi, T; Idone, F; Travierso, C; Chlurazzi, C; Fernandez-Barat, L; Rigol, M; Ramirez, J; Pelosi, P; Chiumello, D; Antonelli, M; Nicolau, DP; Bringue, J; Artigas, A; Guerrero, L; Soy, D; Torres, A
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Affiliations

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias - Author
Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore - Author
Hartford Hospital - Author
Hospital Clinic Barcelona - Author
Humanitas Research Hospital - Author
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - Author
Ospedale Policlinico San Martino - Author
Universitat Autònoma de Barcelona - Author
Universitat de Barcelona - Author
Università Cattolica del Sacro Cuore, Rome - Author
Università degli Studi di Genova - Author
Università degli Studi di Milano - Author
‎ Autonomous Univ Barcelona, Corp Sanitaria Univ Parc Tauli, CIBER Enfermedades Resp, Dept Intens Care Med, Sabadell, Spain - Author
‎ Ctr Invest Red Enfermedades Resp, Madrid, Spain - Author
‎ Fdn Policlin Univ A Gemelli IRCCS, Dept Anesthesiol & Intens Care Med, Rome, Italy - Author
‎ Hartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06115 USA - Author
‎ Hosp Clin Barcelona, Dept Anat Patol, Barcelona, Spain - Author
‎ Hosp Clin Barcelona, Dept Pulmonol, Div Anim Expt, Barcelona, Spain - Author
‎ Humanitas Clin & Res Ctr IRCCS, Milan, Italy - Author
‎ Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain - Author
‎ Inst Invest Biomed August Pi & Sunyer, BITRECS, Barcelona, Spain - Author
‎ IRCCS Oncol & Neurosci, San Martino Policlin Hosp, Anesthesia & Intens Care, Genoa, Italy - Author
‎ Univ Barcelona, Barcelona, Spain - Author
‎ Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Div Med,Pharm Serv, Barcelona, Spain - Author
‎ Univ Cattolica Sacro Cuore, Rome, Italy - Author
‎ Univ Genoa, Dept Surg Sci & Integrated Diagnost, Genoa, Italy - Author
‎ Univ Milan, Milan, Italy - Author
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Abstract

Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacy of telavancin vs. linezolid in a porcine model of severe MRSA pneumonia. In 18 mechanically ventilated pigs (32.11 ± 1.18 kg), 75 mL of 106 CFU/mL of MRSA were administered into each pulmonary lobe. After the onset of pneumonia, pigs were randomized into three groups: control, a group receiving 22.5 mg/kg q24h of telavancin, and a group receiving 10 mg/kg q12h of linezolid intravenously. Tracheal aspirate (TA) and bronchoalveolar lavage (BAL) fluids were cultured every 24 h. After 48 h of treatment, tissue samples were collected from the ventral and dorsal sections of each lobe. Microbiological and histopathological analyses were performed. Lung tissue concentrations differed among the groups (p = 0.019), with the lowest MRSA lung burden in the telavancin group (p < 0.05 vs. control). MRSA was detected in 46.7%, 40.0%, and 21.7% of the lung tissue samples from the control, linezolid, and telavancin groups, respectively (p < 0.001). MRSA concentrations differed among the groups in TA fluid (p = 0.011), but not in BAL fluid. Furthermore, there was no increased risk of kidney injury during telavancin use. Thus, telavancin has higher bactericidal efficacy than linezolid during the first 48 h of treatment in a porcine model of severe MRSA pneumonia. However, studies are needed to confirm the benefits of telavancin in treating MRSA nosocomial pneumonia.Copyright © 2020 American Society for Microbiology.
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Keywords

AminoglycosidesAnimal modelsAnimalsAnti-bacterial agentsLinezolidLipoglycopeptideLipoglycopeptidesManagementMechanical ventilationMethicillin-resistant staphylococcus aureusMrsaMurine modelNosocomial pneumoniaPharmacokineticsPigPigletsPneumonia, staphylococcalPorcine modelSafetySerumSevere pneumoniaSwineTelavancinVancomycinVentilator-associated pneumonia

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antimicrobial Agents And Chemotherapy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 51/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-28:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-28:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 27.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 27 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Torres Martí, Antoni).

the author responsible for correspondence tasks has been Torres Martí, Antoni.

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Awards linked to the item

Support was provided by the Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) (Barcelona, Spain) and the Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES) (Mallorca, Spain). We acknowledge Laura Munoz, Jordi Vila, and Christina Sutherland for their assistance in conducting the study. We thank Anthony Armenta for assisting with the editing of the manuscript in English.
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