{rfName}

Indexed in

License and use

Citations

36

Altmetrics

Grant support

We would like to thank all the patients for their always willing and generous collaboration. All this has been possible thanks to the funding from the Fundacio Marato TV3 and CERCA Programme from Generalitat de Catalunya.

Analysis of institutional authors

Pujol Sobrevia, Maria JesusAuthorGarrido, AliciaAuthorTolosa Sarro, EduardAuthorPerez-Soriano AAuthorRios JAuthorMuñoz EAuthorCompta YAuthorGaig C.AuthorGarrido A.AuthorPainous C.AuthorPlanellás L.AuthorCámara A.AuthorValldeoriola F.AuthorMartí M.j.Corresponding Author

Share

February 7, 2021
Publications
>
Article
No

Progression of Motor and Non-Motor Symptoms in Multiple System Atrophy: A Prospective Study from the Catalan-MSA Registry

Publicated to:Journal Of Parkinsons Disease. 11 (2): 685-694 - 2021-01-01 11(2), DOI: 10.3233/jpd-202332

Authors: Perez-Soriano, Alexandra; Giraldo, Darly M; Rios, Jose; Munoz, Esteban; Compta, Yaroslau; Marti, Maria Jose

Affiliations

‎ Hosp Clin Barcelona, Barcelona, Spain - Author
‎ IDIBAPS, Med Stat Core Facil, Barcelona, Spain - Author
‎ Univ Autonoma Barcelona, Fac Med, Biostat Unit, Barcelona, Spain - Author
‎ Univ Barcelona, European Reference Network Rare Neurol Dis Projec, Parkinsons Dis & Movement Disorders Unit, Neurol Serv,ICN,Hosp Clin,IDIBAPS,CIBERNED CB06 0, Barcelona, Spain - Author

Abstract

Multiple system atrophy (MSA) is a highly debilitating, rare neurodegenerative disorder with two clinical motor variants (parkinsonian or MSA-P and cerebellar or MSA-C). There is a wide span of motor and non-motor symptoms (NMS) that progress over time. We studied the cohort from the Catalan Multiple System Atrophy Registry (CMSAR) to determine which symptoms are most likely to progress throughout a 2-year follow-up.We analyzed baseline, 12-month, and 24-month follow-up evaluations from the 80 cases recruited by the CMSAR. Evaluations included the UMSARS assessment, cognitive and neuropsychiatric evaluations, and a non-motor scale (NMSS-PD). Statistical analysis was done using a Generalized Estimated Equations (GEE) model.Both UMSARS I and II sub-scores significantly increased at 12- and 24-month follow-ups (p?< ?0.001), with a median total score increase of 11 and 12.5 points, respectively. Items on UMSARS I that significantly worsened were mostly motor affecting daily activities. NMS, including urinary and sexual dysfunction, as well as sleep difficulties showed a significant progression on the NMSS-PD; however, other NMS such as postural hypotension, gastrointestinal, and mood dysfunction, although prevalent, did not show a clear progression on clinical scales.Within 24 months and as early as 12 months, MSA cases may experience significant motor worsening, affecting basic daily activities. NMS are prevalent; however, not all clinical scales register a clear progression of symptoms, perhaps suggesting that they are not sensitive enough for non-motor evaluation.

Keywords

AtaxiaCerebellarCohort studiesDysfunctionHumansMotor symptomsMsaMultiple system atrophyNatural-historyNon-motor symptomsParkinson diseaseProspective changesProspective studiesRating-scaleRegistriesSurvival

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Parkinsons Disease due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurology (Clinical).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.1, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 5.52 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 13
  • Scopus: 14
  • Europe PMC: 9

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 25.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 33 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions in news outlets: 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Pérez Soriano, Alejandra) and Last Author ( Catalán MSA Registry (CMSAR) ).

the author responsible for correspondence tasks has been Martí Domènech, M. Josep.