{rfName}
Be

Indexed in

License and use

Citations

31

Altmetrics

Analysis of institutional authors

Serratosa JmAuthor
Share
Publications
>
Review

Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease

Publicated to:International Journal Of Molecular Sciences. 22 (10): - 2021-05-01 22(10), DOI: 10.3390/ijms22105351

Authors: Sanz P, Serratosa JM, Sánchez MP

Affiliations

IIS Fdn Jimenez Diaz, Ctr Investigac Biomed Red Enfermedades Raras CIBE, Madrid 28040, Spain - Author
Inst Biomed Valencia CSIC, Ctr Investigac Biomed Red Enfermedades Raras CIBE, Jaime Roig 11, Valencia 46010, Spain - Author

Abstract

Metformin is a drug in the family of biguanide compounds that is widely used in the treatment of type 2 diabetes (T2D). Interestingly, the therapeutic potential of metformin expands its prescribed use as an anti-diabetic drug. In this sense, it has been described that metformin administration has beneficial effects on different neurological conditions. In this work, we review the beneficial effects of this drug as a neuroprotective agent in different neurological diseases, with a special focus on epileptic disorders and Lafora disease, a particular type of progressive myoclonus epilepsy. In addition, we review the different proposed mechanisms of action of metformin to understand its function at the neurological level.

Keywords
AmpkEpilepsyGpd2Lafora diseaseMechanism of actionMetforminNeurological disorders

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.31, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-21, the following number of citations:

  • WoS: 1
  • Scopus: 19
  • Europe PMC: 11
  • OpenCitations: 20
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-21:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 60 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.