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Analysis of institutional authors

Castrejon-De-Anta NAuthorRamis-Zaldivar JeAuthorSalmeron-Villalobos JAuthorPinyol MAuthorSalaverria IAuthorCampo EAuthorBalague, OCorresponding Author

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Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements

Publicated to:Blood Advances. 6 (7): 2361-2372 - 2022-04-12 6(7), DOI: 10.1182/bloodadvances.2021006034

Authors: Frauenfeld, Leonie; Castrejon-de-Anta, Natalia; Enric Ramis-Zaldivar, Joan; Streich, Sebastian; Salmeron-Villalobos, Julia; Otto, Franziska; Mayer, Annika Katharina; Steinhilber, Julia; Pinyol, Magda; Mankel, Barbara; Ramsower, Colleen; Bonzheim, Irina; Fend, Falko; Rimsza, Lisa M; Salaverria, Itziar; Campo, Elias; Balague, Olga; Quintanilla-Martinez, Leticia

Affiliations

Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain - Author
Eberhard Karls Univ Tubingen, Inst Pathol & Neuropathol, Tubingen, Germany - Author
Hosp Clin Barcelona, Hematopathol Unit, Barcelona, Spain - Author
Inst Investigac Biomed August Pi i Sunyer IDIBAP, Barcelona, Spain - Author
Mayo Clin, Dept Lab Med & Pathol, Phoenix, AZ USA - Author
Mayo Clin, Dept Res, Phoenix, AZ USA - Author
Univ Hosp Tubingen, Comprehens Canc Ctr, Tubingen, Germany - Author
Univ Tubingen, Cluster Excellence iFIT EXC 2180, Tubingen, Germany - Author
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Abstract

Diffuse large B-cell lymphoma (DLBCL) with aberrant co-expression of CD10+BCL6+MUM1+ (DLBCL-AE), classified as germinal center B cell (GCB)-type by the Hans algorithm (HA), were genetically characterized. To capture the complexity of these DLBCL-AE, we used an integrated approach including gene expression profiling (GEP), fluorescence in-situ hybridization (FISH), targeted gene sequencing, and copy number (CN) arrays. According to GEP, 32/54 (59%) cases were classified as GCB-DLBCL, 16/54 (30%) as activated B-cell (ABC)-DLBCL and 6/54 (11%) as unclassifiable. The discrepancy between HA and GEP was 41%. Three genetic subgroups were identified. Group 1 included 13/50 (26%) cases without translocations and mainly showing and ABC/MCD molecular profile. Group 2 comprised 11/50 (22%) cases with IRF4 alterations (DLBCL-IRF4), frequent mutations in IRF4 (82%) and NF-?B pathway genes (MYD88, CARD11, and CD79B), and losses of 17p13.2. Five cases each were classified as GCB- or ABC-type. Group 3 included 26/50 (52%) cases with one or several translocations in BCL2/BCL6/MYC/IGH and GCB/EZB molecular profile predominated. Two cases in this latter group showed complex BCL2/BCL6/IRF4 translocations. DLBCL-IRF4 in adults showed a similar CN profile and share recurrent CARD11 and CD79B mutations when compared to LBCL-IRF4 in pediatric population. However, adult cases showed higher genetic complexity, higher mutational load with frequent MYD88 and KMT2D mutations, and more often ABC-GEP. IRF4 mutations were identified only in IRF4-rearranged cases indicating its potential utility in the diagnostic setting. In conclusion, DLBCL-AE are genetically heterogeneous and enriched in cases with IRF4 alterations. DLBCL-IRF4 in adults has many similarities to the pediatric counterpart.Copyright © 2021 American Society of Hematology.

Keywords

childrenclassificationgenomeoriginsubtypessurvivalAdultAgedAntigens, cdArticleB lymphocyte differentiationBcl2 geneBcl6 geneBcl6 protein, humanCard11 geneCd10 geneCd100 antigenCd79b geneChildChromosomeDiffuse large b cell lymphomaFemaleFluorescence in situ hybridizationGeneGene expressionGene locationGene locusGene mutationGene rearrangementGene-expressionGenética médicaHigh throughput sequencingHumanHumansImmunoglobulin geneIn situ hybridization, fluorescenceInterferon regulatory factor-4Interferon regulatory factorsIrf4 geneLimfomesLymphoma, large b-cell, diffuseLymphomasMajor clinical studyMaleMedical geneticsMum1 geneMutational analysisMyd88 geneMyeloid differentiation factor 88Proto-oncogene proteins c-bcl-2Proto-oncogene proteins c-bcl-6SemaphorinsSomatic hypermutationTranslocation, geneticVery elderly

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Blood Advances due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 13/79, thus managing to position itself as a Q1 (Primer Cuartil), in the category Hematology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.72. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.58 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 23.74 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-15, the following number of citations:

  • WoS: 36
  • Scopus: 39
  • Europe PMC: 18
  • OpenCitations: 37

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 32.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.85.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/199465

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany; United States of America.

the author responsible for correspondence tasks has been Balagué Ponz, Olga.