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Analysis of institutional authors

Lucena, CarmenAuthorSanchez Sanchez, MiguelAuthorMarrades RmAuthorVollmer IAuthorMartinez DAuthorReguart NAuthorAgusti CCorresponding Author

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Integral mediastinal staging in patients with NON-SMALL cell lung cancer and risk factors for occult N2 disease

Publicated to:Respiratory Medicine. 208 107132- - 2023-03-01 208(), DOI: 10.1016/j.rmed.2023.107132

Authors: Lucena, Carmen M; Martin-Deleon, Roberto; Boada, Marc; Marrades, Ramon M; Sanchez, David; Sanchez, Marcelo; Vollmer, Ivan; Martinez, Daniel; Fontana, Ainhoa; Reguart, Noemi; Molins, Laureano; Agusti, Carlos

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Abstract

In patients with non-small cell lung cancer (NSCLC), the presence of abnormal hiliar lymph nodes (clinical N1; cN1), central tumor location and/or tumor size (diameter >3?cm) increases the risk of occult mediastinal metastasis (OMM). This study investigates prospectively the diagnostic value of an integral mediastinal staging (IMS) strategy that combines EndoBronchial Ultrasound-TransBronchial Needle Aspiration (EBUS-TBNA) and Video-Assisted Mediastinoscopy (VAM) in patients with NSCLC at risk of OMM.Patients with NSCLC and radiologically normal mediastinum assessed non-invasively by positron emission tomography and computed tomography of the chest (PET-CT), and OMM risk factors (cN1, central tumor and/or >3?cm) underwent EBUS-TBNA followed by VAM if the former was negative. Those with negative IMS underwent resection surgery of the tumor.EBUS-TBNA identified OMM in 2 out of the 49 patients evaluated (4%) and VAM in 1 of the 47 patients with negative EBUS (2%). Two patients with a negative IMS had OMM at surgery. Overall, the prevalence of OMM was 10%. EBUS-TBNA has a sensitivity of 40%, a negative predictive value (NPV) of 93.6%, and negative likelihood ratio of 0.60 (95%CI:0.30-1.16). The risk of not diagnosing OMM after EBUS was 6% and after IMS was 4.4%.Integral mediastinal staging in patients with NSCLC and clinical risk factors for OMM, does not seem to provide added diagnostic value to that of EBUS-TBNA, except perhaps in patients with cN1 disease who deserve further research.Copyright © 2023 Elsevier Ltd. All rights reserved.

Keywords

endobronchial ultrasoundendosonographyests guidelineslung cancer stagingmediastinoscopyn2 diseasepositron-emission-tomographyAdultArticleCancer patientCancer stagingCancer surgeryCarcinoma, non-small-cell lungClinical articleComputer assisted tomographyControlled studyDiagnostic accuracyDiagnostic test accuracy studyDiagnostic valueEndobronchial ultrasonographyEndobronchial ultrasoundExcisionFemaleHumanHumansLung cancer stagingLung neoplasmsLung tumorLymph nodeLymph nodesMaleMediastinoscopyMediastinumMediastinum metastasisN2 diseaseNeoplasm stagingNon small cell lung cancerPathologyPositron emission tomography computed tomographyPositron emission tomography-computed tomographyPredictive valuePrevalenceRetrospective studiesRetrospective studyRisk assessmentRisk factorTransbronchial aspirationTransbronchial needle aspirationVideo assisted mediastinoscopy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Respiratory Medicine due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pulmonary and Respiratory Medicine.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.13, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-07, the following number of citations:

  • WoS: 2
  • Scopus: 3
  • Europe PMC: 2
  • OpenCitations: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.75.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Agustí Garcia-Navarro, Carles).

the author responsible for correspondence tasks has been Agustí Garcia-Navarro, Carles.