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Analysis of institutional authors

Solé PAuthorGarnica JAuthorMoro JAuthorOrtega MAuthorFandos CAuthorSerra PAuthorSantamaria PCorresponding Author
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Article

A T follicular helper cell origin for T regulatory type 1 cells

Publicated to:Cellular & Molecular Immunology. 20 (5): 489-511 - 2023-05-01 20(5), DOI: 10.1038/s41423-023-00989-z

Authors: Sole, Patricia; Yamanouchi, Jun; Garnica, Josep; Uddin, Muhammad Myn; Clarke, Robert; Moro, Joel; Garabatos, Nahir; Thiessen, Shari; Ortega, Mireia; Singha, Santiswarup; Mondal, Debajyoti; Fandos, Cesar; Saez-Rodriguez, Julio; Yang, Yang; Serra, Pau; Santamaria, Pere

Affiliations

Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. - Author
Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. - Author
Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. psantama@ucalgary.ca. - Author
Heidelberg Univ, Inst Computat Biomed, Fac Med - Author
Inst Invest Biomed August Pi & Sunyer - Author
Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain. - Author
Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. psantama@ucalgary.ca. - Author
Institute of Computational Biomedicine, Faculty of Medicine, Heidelberg University, Heidelberg, Germany. - Author
Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, Calgary - Author
Univ Calgary, Snyder Inst Chron Dis, Cumming Sch Med, Dept Microbiol Immunol & Infect Dis, Calgary - Author
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Abstract

Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+ T cells into T regulatory type 1 (TR1) cells, a subset of interleukin-10-producing Treg cells that do not express FOXP3. The identities of the progenitor(s) and transcriptional regulators of this T-cell subset remain unclear. Here, we show that the peptide-major histocompatibility complex class II (pMHCII) monospecific immunoregulatory T-cell pools that arise in vivo in different genetic backgrounds in response to pMHCII-coated nanoparticles (pMHCII-NPs) are invariably comprised of oligoclonal subpools of T follicular helper (TFH) and TR1 cells with a nearly identical clonotypic composition but different functional properties and transcription factor expression profiles. Pseudotime analyses of scRNAseq data and multidimensional mass cytometry revealed progressive downregulation and upregulation of TFH and TR1 markers, respectively. Furthermore, pMHCII-NPs trigger cognate TR1 cell formation in TFH cell-transfused immunodeficient hosts, and T-cell-specific deletion of Bcl6 or Irf4 blunts both the TFH expansion and TR1 formation induced by pMHCII-NPs. In contrast, deletion of Prdm1 selectively abrogates the TFH-to-TR1 conversion. Bcl6 and Prdm1 are also necessary for anti-CD3 mAb-induced TR1 formation. Thus, TFH cells can differentiate into TR1 cells in vivo, and BLIMP1 is a gatekeeper of this cellular reprogramming event.© 2023. The Author(s).

Keywords
AntigensAutoimmunityCell differentiationGene expression regulationGerminal centerHistocompatibility antigens class iiNanomedicineT follicular helper (tfh) cellsT follicular helper cellsT-lymphocyte subsetsT-lymphocytes, helper-inducerT-lymphocytes, regulatoryT-regulatory type 1 (tr1) cellsTransdifferentiation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cellular & Molecular Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 5/181, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.59. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 11.07 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-09, the following number of citations:

  • WoS: 15
  • Scopus: 16
  • Europe PMC: 9
  • OpenCitations: 19
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 33.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 32 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 42.1.
  • The number of mentions on the social network X (formerly Twitter): 21 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Canada; Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Solé Sánchez, Patricia) and Last Author (Santamaria Vilanova, Pere).

the author responsible for correspondence tasks has been Santamaria Vilanova, Pere.