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Analysis of institutional authors

Herreras ZAuthorCatalan MAuthorPinyol MAuthorGilabert RAuthorJimenez AAuthorOrtega EAuthorChiva-Blanch GCorresponding Author
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Article

Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort

Publicated to:Clinical Nutrition. 42 (7): 1168-1174 - 2023-07-01 42(7), DOI: 10.1016/j.clnu.2023.05.005

Authors: Bujosa, F; Ortega, E; Chiva-Blanch, G; Herreras, Z; Catalán, M; Pinyol, M; Lamuela-Raventos, RM; Martínez-Huélamo, M; Jiménez, A; Gilabert, R

Affiliations

Consorcio Atenc Primaria Eixample CAPSE, Grp Transversal Recerca Atencio Primaria IDIBAPS - Author
Consorcio de Atención Primaria del Eixample (CAPSE), Grup Transversal de Recerca en Atenció Primària, IDIBAPS, 08036 Barcelona, Spain. - Author
Hosp Clin Barcelona, August Pi i Sunyer Biomed Res Inst IDIBAPS, Dept Endocrinol & Nutr - Author
Hosp Clin Barcelona, Ctr Diagnost Imatge IDIBAPS, Vasc Unit - Author
Inst Salud Carlos III, Biomed Network Res Ctr Obes & Nutr Physiopathol CI - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Fragil & Envejecimiento Salu - Author
Univ Oberta Catalunya UOC, Fac Hlth Sci, Rambla Poblenou 156 - Author
Vascular Unit, Centre de Diagnòstic per l'Imatge, IDIBAPS, Hospital Clínic, 08036 Barcelona, Spain. - Author
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Abstract

Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are causatively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study. Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, α-, and β-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging. Results: Subjects with atherosclerosis (n = 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between α-carotene and both large and medium HDL particles, and inverse associations were found between β- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentrations of total carotene compared with subjects without atherosclerosis. Plasma concentrations of carotene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between β- and total carotene with plaque burden remained significant only in women. Conclusions: A diet rich in fruit and vegetables results in higher plasmatic carotene concentrations, which are associated with a lesser atherosclerotic plaque burden. © 2023 The Author(s)

Keywords
AdultAgedAlpha caroteneArterial wall thicknessArticleAtherosclerosisAtherosclerotic plaqueBeta caroteneBlood pressureBody massCaloric intakeCaroteneCarotenesCarotenoidCarotenoidsCarotid arteryCarotid artery diseaseCarotid artery diseasesCarotid intima-media thicknessCarotid ultrasoundClinical trialCohort analysisCohort studiesComplicationCross-sectional studiesCross-sectional studyDiagnostic imagingDiastolic blood pressureDisease burdenFemaleFruit and vegetablesFruit consumptionHigh density lipoprotein cholesterol levelHigh performance liquid chromatographyHumanHumansInflammationIntima media thicknessLipoproteinLiquid chromatography-mass spectrometryMajor clinical studyMaleMediterranean dietPhysical activityPlaque burdenPlaque, atheroscleroticProton nuclear magnetic resonanceQuantitative analysisQuestionnaireRisk factorRisk factorsSociodemographicsSystolic blood pressureTandem mass spectrometryTriacylglycerolTwo-dimensional imagingUltrasoundVegetable consumption

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical Nutrition due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 10/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.37, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Apr 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-04-29, the following number of citations:

  • Scopus: 2
  • OpenCitations: 1
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 62.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 62 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 447.2.
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Bujosa F) and Last Author (Chiva Blanch, Gemma).

the author responsible for correspondence tasks has been Chiva Blanch, Gemma.