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Analysis of institutional authors

Garcia, AliciaAuthorMilà-Guasch MAuthorRamirez SAuthorFos-Domenech JAuthorPozo MAuthorEyre EAuthorObri AAuthorHaddad-Tóvolli RCorresponding AuthorClaret MCorresponding Author
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Article

Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice

Publicated to:Plos Biology. 21 (8): e3002171- - 2023-08-01 21(8), DOI: 10.1371/journal.pbio.3002171

Authors: Milà-Guasch, M; Ramírez, S; Llana, SR; Fos-Domènech, J; Dropmann, LM; Pozo, M; Eyre, E; Gómez-Valadés, AG; Obri, A; Haddad-Tóvolli, R; Claret, M

Affiliations

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. - Author
CIBER Diabet & Enfermedades Metab Asociadas CIBERD, Barcelona, Spain - Author
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Neuronal Control Metab NeuCoMe Lab, Barcelona, Spain - Author
Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. - Author
School of Medicine, Universitat de Barcelona, Barcelona, Spain. - Author
Univ Barcelona, Sch Med, Barcelona, Spain - Author
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Abstract

AU Modern: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly lifestyle is associated with a major consumption of ultra–processed : foods (UPF) due to their practicality and palatability. The ingestion of emulsifiers, a main additive in UPFs, has been related to gut inflammation, microbiota dysbiosis, adiposity, and obesity. Maternal unbalanced nutritional habits during embryonic and perinatal stages perturb offspring’s long–term metabolic health, thus increasing obesity and associated comorbidity risk. However, whether maternal emulsifier consumption influences developmental programming in the offspring remains unknown. Here, we show that, in mice, maternal consumption of dietary emulsifiers (1% carboxymethyl cellulose (CMC) and 1% P80 in drinking water), during gestation and lactation, perturbs the development of hypothalamic energy balance regulation centers of the progeny, leads to metabolic impairments, cognition deficits, and induces anxiety–like traits in a sex–specific manner. Our findings support the notion that maternal consumption of emulsifiers, common additives of UPFs, causes mild metabolic and neuropsychological malprogramming in the progeny. Our data call for nutritional advice during gestation. © 2023 Milà-Guasch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords
AnimalAnimal experimentAnimal modelAnimalsAnxietyArticleBehaviorCognitionCognition disordersCognitive defectCognitive dysfunctionComorbidityDifferential expression analysisDysbiosisEmulsifying agentEnzyme linked immunosorbent assayFemaleFluorescence intensityFood intakeGene set enrichment analysisGlucoseGlucose blood levelGlucose homeostasisGlucose tolerance testHyperglycemiaHypoglycemiaImmunofluorescenceInflammationInsulinInsulin sensitivityLactationLeptinLight dark cycleMaleMediobasal hypothalamusMental healthMiceMouseNonhumanNovel object recognition testObesityOpen field testPolymerase chain reactionPregnancyPrincipal component analysisProgenyQuality controlQuantitative analysisRna sequencingUltra-processed foodUpregulationWeaning

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plos Biology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 6/109, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.21, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 5.49 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-17, the following number of citations:

  • WoS: 1
  • Scopus: 4
  • Europe PMC: 2
  • OpenCitations: 3
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-17:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 21.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 21 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 233.98.
  • The number of mentions on the social network X (formerly Twitter): 41 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mila Guasch, Maria) and Last Author (Claret Carles, Marc).

the authors responsible for correspondence tasks have been Haddad Tovolli, Roberta and Claret Carles, Marc.