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Analysis of institutional authors

Augusta Di Trani, ClaudiaAuthorAranda, FernandoCorresponding Author

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February 13, 2024
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Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

Publicated to:Oncoimmunology. 12 (1): - 2023-12-31 12(1), DOI: 10.1080/2162402X.2022.2147317

Authors: Di Trani, CA; Cirella, A; Arrizabalaga, L; Bella, A; Fernandez-Sendin, M; Russo-Cabrera, JS; Gomar, C; Olivera, I; Bolaños, E; González-Gomariz, J; Alvarez, M; Etxeberria, I; Palencia, B; Teijeira, A; Melero, I; Berraondo, P; Aranda, F; Di Trani, CA; Cirella, A; Arrizabalaga, L; Bella, A; Fernandez-Sendin, M; Russo-Cabrera, JS; Gomar, C; Olivera, I; Bolaños, E; González-Gomariz, J; Alvarez, M; Etxeberria, I; Palencia, B; Teijeira, A; Melero, I; Berraondo, P; Aranda, F; Alvarez, M; Teijeira, A; Melero, I; Berraondo, P; Melero, I; Melero, I

Affiliations

Cima Univ Navarra, Program Immunol & Immunotherapy, Pamplona, Spain - Author
Clin Univ Navarra, Dept Immunol & Immunotherapy, Pamplona, Spain - Author
Clin Univ Navarra, Dept Oncol, Pamplona, Spain - Author
Navarra Inst Hlth Res IdiSNA, Pamplona, Spain - Author
Spanish Ctr Biomed Res Network Oncol CIBERONC, Madrid, Spain - Author
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Abstract

Previous studies have shown that local delivery of tumor antigen-specific CD8(+) T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient condition usually diagnosed when the tumor burden is too large and hence uncontrollable with current treatment options. In this study, we have modeled intracavitary adoptive T cell therapy with OVA-specific OT-I T cells electroporated with IL-12 mRNA to treat B16-OVA and PANC02-OVA tumor spread in the peritoneal cavity. Tumor localization in the omentum and the effects of local T-cell encounter with the tumor antigens were monitored, the gene expression profile evaluated, and the phenotypic reprogramming of several immune subsets was characterized. Intraperitoneal administration of T cells promoted homing to the omentum more effectively than intravenous administration. Transient IL-12 expression was responsible for a favorable reprogramming of the tumor immune microenvironment, longer persistence of transferred T lymphocytes in vivo, and the development of immunity to endogenous antigens following primary tumor eradication. The efficacy of the strategy was at least in part recapitulated with the adoptive transfer of lower affinity transgenic TCR-bearing PMEL-1 T lymphocytes to treat the aggressive intraperitoneally disseminated B16-F10 tumor. Locoregional adoptive transfer of transiently IL-12-armored T cells appears to offer promising therapeutic advantages in terms of anti-tumor efficacy to treat peritoneal carcinomatosis.

Keywords

adoptive cell transferantigencarcinomatosiscd38ifn-gammainterleukin 12interleukin-12locoregional treatmentmrnamurinereceptorsurvivalup-regulationHigh-affinityPeritoneal carcinomatosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal OncoImmunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 45/322, thus managing to position itself as a Q1 (Primer Cuartil), in the category Oncology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.56, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-17, the following number of citations:

  • WoS: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 19.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 19 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.05.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Di Trani, Claudia Augusta) and Last Author (Aranda Vega, Fernando).

the author responsible for correspondence tasks has been Aranda Vega, Fernando.