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Grant support

This research was funded by MCIN/AEI/10.13039/501100011033/FEDER "Una manera de hacer Europa" AGL2017-83477-R and PID2021-122636OB-I00. M. Sierra-Cruz and A Miguens-Gomez received a doctoral research grant from the Marti i Franques programme of the Universitat Rovira i Virgili. M. Pinent and X. Terra are Serra Hunter fellows.

Analysis of institutional authors

Sierra-Cruz, MartaAuthor

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Article

Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues

Publicated to:Journal Of Functional Foods. 105 105566- - 2023-05-06 105(), DOI: 10.1016/j.jff.2023.105566

Authors: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; D'Addario, Claudio; Di Bartolomeo, Martina; Blay, M Teresa; Pinent, Montserrat; Beltran-Debon, Raill; Terra, Ximena

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Abstract

Diet-associated alterations of the intestinal barrier and gut microbiota promote intestinal lipopolysaccharide (LPS) translocation from the lumen to the lamina propria through different pathways, leading to an increase in LPS levels in the plasma known as metabolic endotoxemia.As a pharmacological dose of grape seed proanthocyanidin extract (GSPE) can reduce metabolic endotoxemia of obese rats, in the current study, we aimed to evaluate GSPE modulation of LPS translocation and the un-derlying mechanisms. We performed both an in vitro experiment with Caco-2 cells and an in vivo experiment with Wistar female rats fed a cafeteria (CAF) diet. GSPE was effective in regulating intestinal permeability through the modulation of receptor-mediated endocytosis pathway, as well as the gut microbiota interaction with the endocannabinoid system through epigenetic mechanisms. Our results confirm that GSPE can ameliorate intes-tinal dysfunction and metabolic endotoxemia caused by an excess of dietary lipids by modulating the endotoxin-translocation pathways.

Keywords

Adipose-tissueBarrierCafeteria dietChain fatty-acidsCultureGut microbiotaHepatic mechanismsImpacIntestinal inflammationIntestinal permeabilityMetabolic endotoxemiaMetabolic syndromeMicrobiotaProanthocyanidinsSystemic inflammatio

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Functional Foods due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-08:

  • WoS: 1
  • Scopus: 1
  • OpenCitations: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.85.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Sierra Cruz, Marta) .