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This research was supported by funding from Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe" (PID2021-123167OB-I00 and RED2022-134299-T), CSIC Talent Attraction program (20222AT010) and La Marato de TV3 Foundation (202336-30-31). L.d.l.B.-C. was a recipient of a predoctoral fellowship from Comunidad de Madrid (PIPF-2022/SAL-GL-24824). B.G.-L. was a recipient of a Severo Ochoa FPI predoctoral fellowship from Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion (PRE2022-104403). O.T.-C. was supported by funding from Fondo de Investigacion Sanitaria (FIS) Contratos Miguel Servet tipo II (CPII22/00006).

Analysis of institutional authors

Tura-Ceide, OlgaAuthor
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Review

The Relevance of the Endothelium in Cardiopulmonary Disorders

Publicated to:International Journal Of Molecular Sciences. 25 (17): 9260- - 2024-09-01 25(17), DOI: 10.3390/ijms25179260

Authors: de la Bastida-casero, L; García-León, B; Oliver, E; Tura-Ceide, O

Affiliations

CSIC, Ctr Invest Biol Margarita Salas CIB, Madrid 28040, Spain - Author
Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain - Author
Ctr Invest Biomed Red Enfermedades Respiratorias C, Madrid 28029, Spain - Author
Ctr Nacl Invest Cardiovasc CNIC, Madrid 28039, Spain - Author
Dr Josep Trueta Univ Hosp Girona, Santa Caterina Hosp Salt, Translat Res Grp Cardiovasc Resp Dis CAREs, Girona 17190, Spain - Author
Inst Invest Biomed Girona IDIBGI CERCA, Girona 17190, Spain - Author
Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Dept Pulm Med,Serv Pneumol, Barcelona 08036, Spain - Author
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Abstract

The endothelium is a cell monolayer that lines vessels and separates tissues from blood flow. Endothelial cells (ECs) have a multitude of functions, including regulating blood flow and systemic perfusion through changes in vessel diameter. When an injury occurs, the endothelium is affected by altering its functions and structure, which leads to endothelial dysfunction, a characteristic of many vascular diseases. Understanding the role that the endothelium plays in pulmonary vascular and cardiopulmonary diseases, and exploring new therapeutic strategies is of utmost importance to advance clinically. Currently, there are several treatments able to improve patients' quality of life, however, none are effective nor curative. This review examines the critical role of the endothelium in the pulmonary vasculature, investigating the alterations that occur in ECs and their consequences for blood vessels and potential molecular targets to regulate its alterations. Additionally, we delve into promising non-pharmacological therapeutic strategies, such as exercise and diet. The significance of the endothelium in cardiopulmonary disorders is increasingly being recognized, making ECs a relevant target for novel therapies aimed at preserving their functional and structural integrity.

Keywords
Acute respiratory distress syndromeAngiogènesiAnimalsBlood flowBlood vessel diameterCardiopulmonary disordersCardiovascular diseasesCardiovascular-diseaseCell metabolismChronic obstructive pulmonary distressCor pulmonaleCoronavirus disease 2019Covid-19DietDysfunctionEndothelial cellsEndothelial dysfunctionEndotheliumEndothelium cellEndothelium, vascularEtiologyExerciseHealthHeart diseasesHumanHumansHypertensionLung blood vesselLung diseasesMesenchymal transitionPulmonaryPulmonary hypertensionRespiratory distressRespiratory distress syndromeReviewRisk-factorsTherapeutic strategieTherapeutic strategiesTherapyVascular disease

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 68/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.95.
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.