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This research was supported by funding from Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe" (PID2021-123167OB-I00 and RED2022-134299-T), CSIC Talent Attraction program (20222AT010) and La Marato de TV3 Foundation (202336-30-31). L.d.l.B.-C. was a recipient of a predoctoral fellowship from Comunidad de Madrid (PIPF-2022/SAL-GL-24824). B.G.-L. was a recipient of a Severo Ochoa FPI predoctoral fellowship from Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion (PRE2022-104403). O.T.-C. was supported by funding from Fondo de Investigacion Sanitaria (FIS) Contratos Miguel Servet tipo II (CPII22/00006).

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The Relevance of the Endothelium in Cardiopulmonary Disorders

Publicado en:International Journal Of Molecular Sciences. 25 (17): 9260- - 2024-09-01 25(17), DOI: 10.3390/ijms25179260

Autores: de la Bastida-casero, L; García-León, B; Oliver, E; Tura-Ceide, O

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Resumen

The endothelium is a cell monolayer that lines vessels and separates tissues from blood flow. Endothelial cells (ECs) have a multitude of functions, including regulating blood flow and systemic perfusion through changes in vessel diameter. When an injury occurs, the endothelium is affected by altering its functions and structure, which leads to endothelial dysfunction, a characteristic of many vascular diseases. Understanding the role that the endothelium plays in pulmonary vascular and cardiopulmonary diseases, and exploring new therapeutic strategies is of utmost importance to advance clinically. Currently, there are several treatments able to improve patients' quality of life, however, none are effective nor curative. This review examines the critical role of the endothelium in the pulmonary vasculature, investigating the alterations that occur in ECs and their consequences for blood vessels and potential molecular targets to regulate its alterations. Additionally, we delve into promising non-pharmacological therapeutic strategies, such as exercise and diet. The significance of the endothelium in cardiopulmonary disorders is increasingly being recognized, making ECs a relevant target for novel therapies aimed at preserving their functional and structural integrity.

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