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Analysis of institutional authors

Alia-Navarro, VictorAuthor

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Case report: Efficacy of immunotherapy as conversion therapy in dMMR/MSI-H colorectal cancer: a case series and review of the literature

Publicated to:Frontiers In Immunology. 15 1352262- - 2024-02-01 15(), DOI: 10.3389/fimmu.2024.1352262

Authors: San-Roman-Gil, Maria; Martinez-Delfrade, Inigo; Albarran-Fernandez, Victor; Guerrero-Serrano, Patricia; Pozas-Perez, Javier; Chamorro-Perez, Jesus; Rosero-Rodriguez, Diana; Sotoca-Rubio, Pilar; Barrill-Corpa, Ana Maria; Alia-Navarro, Victor; Gonzalez-Merino, Carlos; Garcia-de-Quevedo-Suero, Coral; Lopez, Victoria; Ruz-Caracuel, Ignacio; Perna-Monroy, Cristian; Ferreiro-Monteagudo, Reyes

Affiliations

Hosp Univ Ramon & Cajal, Med Oncol Dept, Madrid, Spain - Author
Hosp Univ Ramon & Cajal, Pathol Dept, Madrid, Spain - Author
Royal Marsden Hosp, Med Oncol Dept, London, England - Author

Abstract

Immunotherapy has demonstrated a role in the therapeutic landscape of a small subset of patients with colorectal carcinoma (CRC) that harbor a microsatellite instability (MSI-H) status due to a deficient DNA mismatch repair (dMMR) system. The remarkable responses to immune checkpoint inhibitors (ICIs) are now being tested in the neoadjuvant setting in localized CRC, where the dMMR/MSI-H status can be found in up to 15% of patients, with remarkable results obtained in NICHE2 and 3 trials, among others. This case series aims to report our experience at a tertiary center and provide a comprehensive analysis of the possible questions and challenges to overcome if ICIs were established as standard of care in a neoadjuvant setting, as well as the potential role they may have as conversion therapy not only in locoregional advanced CRC but also in oligometastatic disease.

Keywords

Clinical-practice guidelinesColon-cancerColorectal cancerConversion therapDiagnosisImmunotherapyIpilimumabMicrosatellite instabilityMutatioNeoadjuvantNeoadjuvant immunotherapyOligometastatic

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 37/181, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.25.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.