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This project was supported by Grant of Instituto Salud Carlos III (PI17/000615), IPs Miguel Blanca and Maria Luisa Somoza, FEDER. Allergy Service, Hospital Infanta Leonor, Madrid, Spain, and the Network Aradyal (Instituto Salud Carlos III).

Analysis of institutional authors

Ruano-Zaragoza, MariaCorresponding Author

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May 16, 2025
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Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients

Publicated to:International Archives Of Allergy And Immunology. 182 (5): 425-432 - 2021-01-01 182(5), DOI: 10.1159/000511977

Authors: Ruano-Zaragoza, Maria; Somoza, Maria Luisa; Jimenez-Rodriguez, Teodorikez Wilfox; Soriano-Gomis, Victor; Gonzalez-Delgado, Purificacion; Esteban-Rodriguez, Angel; Palazon-Bru, Antonio; Blanca, Miguel; Fernandez-Sanchez, Javier

Affiliations

Alicante Gen Univ Hosp ISABIAL, Allergy Sect, ARADyAL Spanish Network, Alicante, Spain - Author
Alicante Gen Univ Hosp, Clin Anal Dept, Alicante, Spain - Author
Hosp Infanta Leonor, Allergy Serv, Madrid, Spain - Author
Infanta Leonor Univ Hosp, Sect Allergy, Madrid, Spain - Author
Miguel Hernandez Univ, Clin Med Dept, Alicante, Spain - Author
Miguel Hernandez Univ, PhD Program Publ Hlth Med & Surg Sci, Alicante, Spain - Author
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Abstract

Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. Methods: This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. Results: Our sample consisted of 421 people with a mean age of 33.25 years (range 16-68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. Conclusion: Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.

Keywords

anaphylaxiscomponent-resolved diagnosislipid transfer proteinspru p 3AdolescentAdultAgedAnaphylaxisAntigens, plantCarrier proteinsComponent-resolved diagnosisCross-sectional studiesDiagnosis, differentialFemaleFood allergyHumansImmunoglobulin eIncidenceLipid transfer proteinLipid transfer proteinsMaleMicroarrayMiddle agedPeachPlant proteinsPlant-foodsPollenPollinosisPrevalencePru p 3Pru p 3 allergenReactivity profilesRecombinant allergensRisk assessmentRisk factorRisk factorsSufficienSufficientYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Archives Of Allergy And Immunology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category . Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Allergy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.16. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 5.41 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 18
  • Europe PMC: 12

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 31.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 33 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.5.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Ruano Zaragoza, María) .

the author responsible for correspondence tasks has been Ruano Zaragoza, María.