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Analysis of institutional authors

Rabaneda-Lombarte NAuthorSerratosa JAuthorSaura JAuthorSolá CCorresponding Author

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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease

Publicated to:Journal Of Neuroinflammation. 18 (1): 88- - 2021-04-06 18(1), DOI: 10.1186/s12974-021-02132-z

Authors: Rabaneda-Lombarte, N; Serratosa, J; Solà, C; Saura, J; Bové, J; Vila, M

Affiliations

Institució Catalana de Recerca i Estudis Avançats - Author
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - Author
Universitat de Barcelona - Author
Vall d’Hebron Research Institute - Author
‎ Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain - Author
‎ Inst Invest Biomed August Pi & Sunyer IDIBAPS, Dept Cerebral Ischemia & Neurodegenerat, Inst Invest Biomed Barcelona, Consejo Super Invest Cient CSIC, Barcelona, Spain - Author
‎ Univ Barcelona, Sch Med, Biochem & Mol Biol Unit, IDIBAPS, Barcelona, Spain - Author
‎ Vall dHebron Res Inst CIBERNED, Barcelona, Spain - Author
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Abstract

Background: It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD). Consequently, the modulation of microglial activation is a potential therapeutic target to be taken into account to act against the dopaminergic neurodegeneration occurring in this neurological disorder. Several soluble and membrane-associated inhibitory mechanisms contribute to maintaining microglial cells in a quiescent/surveillant phenotype in physiological conditions. However, the presence of activated microglial cells in the brain in PD patients suggests that these mechanisms have been somehow overloaded. We focused our interest on one of the membrane-associated mechanisms, the CD200-CD200R1 ligand-receptor pair. Methods: The acute MPTP experimental mouse model of PD was used to study the temporal pattern of mRNA expression of CD200 and CD200R1 in the context of MPTP-induced dopaminergic neurodegeneration and neuroinflammation. Dopaminergic damage was assessed by tyrosine hydroxylase (TH) immunoreactivity, and neuroinflammation was evaluated by the mRNA expression of inflammatory markers and IBA1 and GFAP immunohistochemistry. The effect of the modulation of the CD200-CD200R1 system on MPTP-induced damage was determined by using a CD200R1 agonist or CD200 KO mice. Results: MPTP administration resulted in a progressive decrease in TH-positive fibres in the striatum and TH-positive neurons in the substantia nigra pars compacta, which were accompanied by transient astrogliosis, microgliosis and expression of pro- and anti-inflammatory markers. CD200 mRNA levels rapidly decreased in the ventral midbrain after MPTP treatment, while a transient decrease of CD200R1 mRNA expression was repeatedly observed in this brain area at earlier and later phases. By contrast, a transient increase in CD200R1 expression was observed in striatum. The administration of a CD200R1 agonist resulted in the inhibition of MPTP-induced dopaminergic neurodegeneration, while microglial cells showed signs of earlier activation in CD200-deficient mice. Conclusions: Collectively, these findings provide evidence for a correlation between CD200-CD200R1 alterations, glial activation and neuronal loss. CD200R1 stimulation reduces MPTP-induced loss of dopaminergic neurons, and CD200 deficiency results in earlier microglial activation, suggesting that the potentiation of CD200R1 signalling is a possible approach to controlling neuroinflammation and neuronal death in PD.

Keywords

cd200 ko micecd200-cd200r1 systemcd200fcgliaimmune responsemicrogliamptpneuroinflammationparkinson&#8217s diseaseAnimalsCd200 ko miceCd200-cd200r1 systemCd200fcDrug delivery systemsFemaleGliaImmune responseImmunoglobulin gMalaltia de parkinsonMaleMiceMice, inbred c57blMice, knockoutMicrogliaMptpNeuroinflammationOrexin receptorsParkinson's diseaseParkinsonian disordersParkinson’s diseaseResposta immunitària

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Neuroinflammation due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 24/275, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.06, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 5.57 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-19, the following number of citations:

  • WoS: 18
  • Scopus: 23
  • Europe PMC: 9
  • OpenCitations: 19

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 34.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 34 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 14.45.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/182813

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rabaneda Lombarte, Neus) and Last Author (Solà Subirana, Carme).

the author responsible for correspondence tasks has been Solà Subirana, Carme.