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Analysis of institutional authors

Bartra CAuthorSanfeliu, CAuthor

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January 5, 2022
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2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

Publicated to: Pharmaceuticals. 14 (12): 1323- - 2021-12-01 14(12), DOI: 10.3390/ph14121323

Authors:

Martín-López, J; Codony, S; Bartra, C; Morisseau, C; Loza, MI; Sanfeliu, C; Hammock, BD; Brea, J; Vázquez, S
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Affiliations

Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA. - Author
Department of Entomology and Nematology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA. - Author
Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain. - Author
IDIBAPS, C Rosello 161, Barcelona 08036, Spain - Author
Inst Invest Biomed Barcelona IIBB, CSIC, C Rosello 161, Barcelona 08036, Spain - Author
Institut d'Investigacions Biomèdiques de Barcelona (IIBB), CSIC and IDIBAPS, C/Roselló 161, 08036 Barcelona, Spain. - Author
Institute of Biomedicine (IBUB), Universitat de Barcelona, Avinguda Joan XXIII 27-31, 08028 Barcelona, Spain. - Author
Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avinguda Joan XXIII 27-31, 08028 Barcelona, Spain. - Author
Univ Barcelona, Fac Farm & Ciencies Alimentacio, Unitat Associada CSIC, Lab Quim Farmaceut, Avinguda Joan XXIII 27-31, Barcelona 08028, Spain - Author
Univ Barcelona, Inst Biomed IBUB, Avinguda Joan XXIII 27-31, Barcelona 08028, Spain - Author
Univ Calif Davis, Comprehens Canc Ctr, One Shields Ave, Davis, CA 95616 USA - Author
Univ Calif Davis, Dept Entomol & Nematol, One Shields Ave, Davis, CA 95616 USA - Author
Univ Santiago De Compostela USC, Dept Farmacol Farm & Tecnol Farmaceut, Drug Screening Platform Biofarma Res Grp, CIMUS Res Ctr, Santiago De Compostela 15782, Spain - Author
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Abstract

The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many contain highly lipophilic substituents limiting their availability. Recently, a new series of benzohomoadamantane-based ureas endowed with potent inhibitory activity for the human and murine sEH was reported. However, their very low microsomal stability prevented further development. Herein, a new series of benzohomoadamantane-based amides were synthetized, fully characterized, and evaluated as sEHI. Most of these amides were endowed with excellent inhibitory potencies. A selected compound displayed anti-inflammatory effects with higher effectiveness than the reference sEHI, TPPU.
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Keywords

amideaminesbenzohomoadamantanedmpk propertiesfatty-acidspainpharmacodynamicspharmacokineticspiperidinesinglesoluble epoxide hydrolasetargetAmideBenzohomoadamantaneDmpk propertiesNmda receptor antagonistPiperidineSoluble epoxide hydrolase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Pharmaceuticals due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 4
  • Scopus: 2
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

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Awards linked to the item

This research was funded by the Spanish Ministerio de Economia, Industria y Competitividad (Grants SAF2017-82771-R to S.V., PID2019-106285RB-C22 to C.S.), Grant PID2020-118127RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF A way of making Europe to S.V., the Xunta de Galicia (ED431G 2019/02 and ED431C 2018/21), the Generalitat de Catalunya (2017 SGR 106, 2017 SGR 124 and 2017 SGR 1707). S.C. acknowledges a PhD fellowship from the Universitat de Barcelona (APIF grant). Partial support was provided by NIH-NIEHS River Award R35 ES03443, NIH-NIEHS Superfund Program P42 ES004699, NINDS R01 DK107767, and NIDDK R01 DK103616 to B.D.H. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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