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Grant support

This work was supported in part by grants from Plan Nacional de I+D+I and cofinanced by the ISCIII-Subdireccion General de Evaluacion y Formento de la Sanitaria-and the Fondo Europeo de Desarrollo Regional (ISCIII-FEDER; PI21/00316 to TA); Fundaci ' o Marat ' o de TV3 (37/C/2021, TA), Torrons Vicens Foundation (PFNR0144 to TA); 2021 Invest AEP Grant to TA (PI047351), and 2019 Invest-AEP Support to GO from Pediatric Spanish Society.

Analysis of institutional authors

Olivé-Cirera GAuthorArmangue TCorresponding Author
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Editorial Material

Pearls & Oy-sters: Tumefactive Demyelinating Lesions With MOG Antibodies Preceding Late-Infantile Metachromatic Leukodystrophy

Publicated to:Neurology. 99 (19): 10.1212/WNL.0000000000201230-861 - 2022-11-08 99(19), DOI: 10.1212/wnl.0000000000201230

Authors: Olive-Cirera, Gemma; Jesus Martinez-Gonzalez, Maria; Armangue, Thais

Affiliations

Cruces Univ Hosp, Pediat Neurol Unit, Baracaldo, Spain - Author
Hosp Parc Tauli Sabadell, Pediat Neurol Unit, Barcelona, Spain - Author
Neurology Department, Hospital de Cruces, Bilbao, Spain. - Author
Univ Barcelona, IDIBAPS Hosp Clin, Neuroimmunol Program, Barcelona, Spain - Author
Univ Barcelona, Pediat Neuroimmunol Unit, St Joan de Deu Childrens Hosp, Barcelona, Spain - Author
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Abstract

The development of acute neurologic dysfunction associated with tumefactive demyelinating lesions and mild diffuse involvement of the corpus callosum has been described in children as a sentinel event that may allow diagnosis of juvenile metachromatic leukodystrophy (MLD) at an early and potentially treatable stage. We report a child who developed this clinico-radiologic pattern associated with myelin oligodendrocyte glycoprotein antibodies several months before the onset of progressive symptoms of late infantile MLD.

Keywords
AntibodiesAntibodyArsa geneArticleArylsulfataseAtaxiaBaclofenCase reportCerebrospinal fluid analysisChildClinical articleComplicationConvergent strabismusCorpus callosumDemyelinating diseaseDiazepamDisease exacerbationDystoniaDystonic disorderEnzyme replacementFollow upGait disorderGeneHumanHuman cellHumansHyperreflexiaLanguage disabilityLeukocyte countLeukodystrophy, metachromaticMaleMetachromatic leukodystrophyMriMyelin oligodendrocyte glycoproteinMyelin oligodendrocyte glycoprotein antibodyMyelin-oligodendrocyte glycoproteinNeurologic diseaseNuclear magnetic resonance imagingPleocytosisPreschool childProtein antibodySentinel eventSomnolenceSpasticitySteroidSulfatideTrihexyphenidylTumefactive demyelinating lesionUnclassified drugWhite matter

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neurology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 12/212, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.07, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-12, the following number of citations:

  • WoS: 2
  • Scopus: 2
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 19.25.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 31 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Olivé Cirera, Gemma) and Last Author (Armangué Salvador, Thais).

the author responsible for correspondence tasks has been Armangué Salvador, Thais.