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Martinez, JaAuthorSoler, NAuthor
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Differences in Drug-Susceptibility Patterns between Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium chimaera Clinical Isolates: Prospective 8.5-Year Analysis by Three Laboratories

Publicated to:Antibiotics. 12 (1): 64- - 2023-01-01 12(1), DOI: 10.3390/antibiotics12010064

Authors: Fernandez-Pittol, M; Batista-Arnau, S; Roman, A; San Nicolas, L; Oliver, L; Gonzalez-Moreno, O; Martinez, JA; Amaro-Rodriguez, R; Soler, N; Gene, A; Gonzalez-Cuevas, A; Tudo, G; Gonzalez-Martin, J

Affiliations

1.03.04 - Infecció nosocomial. Institut d'Investigacions Biomèdiques August Pi i Sunyer - Author
Hosp Clin Barcelona, Serv Microbiol, CDB, c-Villarroel 170 - Author
Inst Global Hlth, ISGLOBAL, c-Rossello 132 - Author
Inst Salud Carlos III, CIBER Infect Dis CIBERINFEC - Author
Lab Hosp Sant Joan Deu - Author
SYNLAB Diagnost Globales, Dept Microbiol & Parasitol - Author
Univ Barcelona, Dept Fonaments Clin, Fac Med & Ciencies Salut, c-Casanova 143 - Author
Univ Barcelona, Hosp Clin, Dept Pneumonol - Author
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Abstract

Background: It has been suggested that Mycobacterium avium, Mycobacterium intracellulare, and M. chimaera have differential drug susceptibility patterns. We prospectively analyzed and compared the drug susceptibility patterns among these species over an 8.5-year period. Methods: A microdilution method (Slomyco((R))) was performed for drug susceptibility testing of 402 M. avium, 273 M. intracellulare, and 139 M. chimaera clinical isolates. Results: M. avium showed significantly higher resistance to moxifloxacin, ciprofloxacin, rifampicin, ethambutol, streptomycin, linezolid, cotrimoxazole, and clarithromycin. M. avium also showed higher minimum inhibitory concentrations (MIC) than M. intracellulare and M. chimaera against all drugs except ethionamide, to which M. intracellulare and M. chimaera showed greater resistance. Conclusions: Our series demonstrated differential drug resistance patterns among the most frequent M. avium complex species. M. avium was more resistant than M. intracellulare and M. chimaera versus eight antibiotics and showed greater MIC values to most of the antibiotics studied. These data suggest that knowledge of the local distribution and susceptibility profiles of these pathogens is essential for adequate clinical management.

Keywords
AstDiseasesGenotypeMac-complexMic-valuesSusceptibility profiles

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antibiotics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 69/354, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.16. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 4.93 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-22, the following number of citations:

  • WoS: 5
  • Scopus: 11
  • Europe PMC: 2
  • OpenCitations: 6
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.