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Analysis of institutional authors

Jodar, Mercedes Soledad NabaesCorresponding Author

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February 20, 2025
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Article

The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37

Publicated to: Viruses-Basel. 15 (6): 1382- - 2023-06-01 15(6), DOI: 10.3390/v15061382

Authors:

Jodar, Mercedes Soledad Nabaes; Torres, Carolina; Mojsiejczuk, Laura; Acuna, Dolores; Valinotto, Laura Elena; Goya, Stephanie; Natale, Monica; Lusso, Silvina; Alexay, Sofia; Amadio, Ariel; Irazoqui, Matias; Fernandez, Franco; Acevedo, Maria Elina; Lopez, Cristina Alvarez; Angelletti, Andres; Aulicino, Paula; Bolatti, Elisa; Bruses, Bettina; Cacciahue, Marco; Cavatorta, Ana; Cerri, Agustina; Cordero, Andres; Debat, Humberto; Santos, Maria Jose Dus; Eberhardt, Maria Florencia; Ercole, Regina; Espul, Carlos; Farber, Marisa; Fay, Fabian; Fernandez, Ailen; Ferrini, Florencia; Formichelli, Laura; Ceballos, Santiago; Gallego, Fernando; Giri, Adriana; Gismondi, Maria; Acevedo, Raul Maximiliano; Gramundi, Ivan; Ibanez, Maria Eugenia; Konig, Guido; Leiva, Viviana; Lorenzini Campos, Melina; Lucero, Horacio; Marquez, Nathalie; Mazzeo, Melina; Mistchenko, Alicia Susana; Montoto, Luciana; Munoz, Marianne; Nadalich, Victoria; Nardi, Cristina; Ortiz, Belen; Pianciola, Luis; Pintos, Carolina; Puebla, Andrea; Rastellini, Carolina; Rojas, Alejandro Ezequiel; Sfalcin, Javier; Suarez, Ariel; Theaux, Clara; Thomas, Guillermo; Tittarelli, Estefania; Toro, Rosana; Villanova, Vanina; Wenk, Gretel; Ziehm, Cecilia; Zimmermann, Maria Carla; Zunino, Sebastian; Pais, Proyecto; Viegas, Mariana
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Affiliations

CIBIC Lab, Pte Roca 746, RA-2000 Rosario, Argentina - Author
Comis Invest Cient Prov Buenos Aires, Camino Gen Belgrano & 526, RA-1900 La Plata, Argentina - Author
Consejo Nacl Invest Cient & Tecn CONICET, Godoy Cruz 2390, RA-2915 Buenos Aires, Argentina - Author
Consejo Nacl Invest Cient & Tecn, Grp Virol Humana, Inst Biol Mol & Celular Rosario, Suipacha 590, RA-2000 Rosario, Argentina - Author
Consejo Nacl Invest Cient & Tecn, Inst Biotecnol, Inst Agrobiotecnol & Biol Mol INTA, RA-1686 Hurlingham, Argentina - Author
Consejo Nacl Invest Cient & Tecn, Inst Invest Cadena Lactea IDICAl, INTA, Ruta 34 Km 227, RA-2300 Rafaela, Argentina - Author
Consejo Nacl Invest Cient & Tecn, Inst Virol & Innovac Tecnol INTA, RA-1686 Hurlingham, Argentina - Author
Consorcio Argentino Genom SARS CoV 2, Proyecto Argentino Interinst Genom SARS CoV 2, Gallo 1330, RA-1425 Buenos Aires, Argentina - Author
HIEAyC San Juan de Dios, Lab Virol, Calles 27 & 70, RA-1900 La Plata, Argentina - Author
Hosp Aleman, Biol Mol Lab Cent, Ave Pueyrredon 1640, RA-1118 Buenos Aires, Argentina - Author
Hosp Blas L Dubarry, Lab Virol Mol, Calle 12 825, RA-6600 Mercedes, Argentina - Author
Hosp Gen Agudos, Lab Biol Mol, Diaz Velez 5044, RA-1405 Buenos Aires, Argentina - Author
Hosp Ninos Dr Ricardo Gutierrez, Lab Virol, Gallo 1330, RA-1425 Buenos Aires, Argentina - Author
Hosp Pediat Prof Juan P Garrahan, Lab Biol Celular & Retrovirus, Ave Brasil 1175, RA-1260 Buenos Aires, Argentina - Author
Hosp Pedro de Elizalde, Lab Biol Mol, Ave Manuel A Montes Oca 1402, RA-1270 Buenos Aires, Argentina - Author
Hosp Reg Ushuaia, Ave 12 Octubre & Maipu, RA-9410 Ushuaia, Argentina - Author
IACA Labs, Dept Biol & Genet Mol, San Martin 68, RA-8000 Bahia Blanca, Argentina - Author
Inst Invest Bacteriol & Virol Mol IbaViM, Junin 956, RA-1113 Buenos Aires, Argentina - Author
Inst Nacl Tecnol Agr, Inst Patol Vegetal, Ctr Invest Agr, Camino 60 Cuadras Km 5,5, RA-5020 Cordoba, Argentina - Author
Lab Mixto Biotecnol Acuat, Ave Eduardo Carrasco & Cordiviola, RA-2000 Rosario, Argentina - Author
Lab Salud Publ, Talcahuano 2194, RA-5501 Godoy Cruz, Argentina - Author
Minist Salud Prov Mendoza, Direcc Epidemiol & Red Labs, RA-5500 Mendoza, Argentina - Author
Minist Salud, Lab Cent Ciudad Neuquen, Gregorio Martinez 65, RA-8300 Neuquen, Argentina - Author
Univ Nacl Hurlingham, Lab Diagnost UNIDAD COVID, RA-1686 Hurlingham, Argentina - Author
Univ Nacl La Plata, Fac Ciencias Exactas, Lab Salud Publ, Calle 1 & 47, RA-1900 La Plata, Argentina - Author
Univ Nacl Nordeste, Fac Med, Lab Med Genom, RA-1430 Cordoba, Argentina - Author
Univ Nacl Nordeste, Inst Med Reg, Ave Las Heras 727, RA-3500 Resistencia, Argentina - Author
Univ Nacl Rosario UNR, Fac Ciencias Bioquim & Farmaceut, Ctr Tecnol Salud Publ, Suipacha 531, RA-2000 Rosario, Argentina - Author
Univ Nacl Tierra Del Fuego UNTDF, Inst Ciencias Polares Ambiente & Recursos Nat ICP, Houssay 200, RA-9410 Ushuaia, Argentina - Author
Univ Nacl Tierra Del Fuego, Cadic Conicet, Houssay 200, RA-9410 Ushuaia, Argentina - Author
UNNE, Inst Bot Nordeste, Sargento Juan Bautista Cabral 2131, RA-3400 Corrientes, Argentina - Author
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Abstract

The second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda variant in Argentina, from its initial entry into the country until its detection ceased. Molecular surveillance was conducted on 9356 samples from Argentina between October 2020 and April 2022, and sequencing, phylogenetic, and phylogeographic analyses were performed. Our findings revealed that the Lambda variant was first detected in Argentina in January 2021 and steadily increased in frequency until it peaked in April 2021, with continued detection throughout the year. Phylodynamic analyses showed that at least 18 introductions of the Lambda variant into the country occurred, with nine of them having evidence of onward local transmission. The spatial--temporal reconstruction showed that Argentine clades were associated with Lambda sequences from Latin America and suggested an initial diversification in the Metropolitan Area of Buenos Aires before spreading to other regions in Argentina. Genetic analyses of genome sequences allowed us to describe the mutational patterns of the Argentine Lambda sequences and detect the emergence of rare mutations in an immunocompromised patient. Our study highlights the importance of genomic surveillance in identifying the introduction and geographical distribution of the SARS-CoV-2 Lambda variant, as well as in monitoring the emergence of mutations that could be involved in the evolutionary leaps that characterize variants of concern.
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Keywords

AlignmenArgentinaCovid-19EvolutionHumansLambdaMutationPerformancePhylodynamiPhylodynamicPhylogenySars-cov-2South americaVariants

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Viruses-Basel due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 2
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Nabaes Jodar, Mercedes Soledad) .

the author responsible for correspondence tasks has been Nabaes Jodar, Mercedes Soledad.

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Awards linked to the item

The sequencing strategy was supported by Proyecto IP COVID-19 N degrees 08 (Ministerio de Ciencia, Tecnologia e Innovacion, Argentina) and Focem COF 03/11 COVID-19 (Fondo para la Convergencia Estructural del MERCOSUR).
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